Entry
Name
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase;
2-keto-3-deoxygluconate aldolase (ambiguous);
KDGA (ambiguous)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-6-phospho-D-gluconate/2-dehydro-3-deoxy-6-phospho-D-galactonate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)
Reaction(IUBMB)
(1) 2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate [RN:
R05605 ];
(2) 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate [RN:
R01064 ]
Reaction(KEGG)
Substrate
2-dehydro-3-deoxy-6-phospho-D-gluconate [CPD:
C04442 ];
2-dehydro-3-deoxy-6-phospho-D-galactonate [CPD:
C01286 ]
Product
pyruvate [CPD:
C00022 ];
D-glyceraldehyde 3-phosphate [CPD:
C00118 ]
Comment
In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro-3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency. In vitro the enzyme can also catalyse the cleavage of the non-phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with much lower catalytic efficiency. cf. EC
4.1.2.21 , 2-dehydro-3-deoxy-6-phosphogalactonate aldolase, and EC
4.1.2.14 , 2-dehydro-3-deoxy-phosphogluconate aldolase.
History
EC 4.1.2.55 created 2014
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K11395 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
Genes
TVO : TVG0663048(TVG0663048)
ABRI : DFR85_02045 DFR85_14740
» show all
Taxonomy
Reference
Authors
Buchanan CL, Connaris H, Danson MJ, Reeve CD, Hough DW
Title
An extremely thermostable aldolase from Sulfolobus solfataricus with specificity for non-phosphorylated substrates.
Journal
Sequence
Reference
Authors
Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ
Title
Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus.
Journal
Sequence
Reference
Authors
Wolterink-van Loo S, van Eerde A, Siemerink MA, Akerboom J, Dijkstra BW, van der Oost J
Title
Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolases.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.55
ExPASy - ENZYME nomenclature database: 4.1.2.55