KEGG ENZYME: 4.1.2.64

ENZYME: 4.1.2.64

Entry

EC 4.1.2.64                 Enzyme

Name

2-dehydro-3-deoxy-L-fuconate aldolase;
2-keto-3-deoxy-L-fuconate aldolase;
L-2-keto-3-deoxyfuconate aldolase;
fucH (gene name)

Class

Lyases;
Carbon-carbon lyases;
Aldehyde-lyases

Sysname

2-dehydro-3-deoxy-L-fuconate (S)-lactaldehyde-lyase (pyruvate-forming)

Reaction(IUBMB)

2-dehydro-3-deoxy-L-fuconate = pyruvate + (S)-lactaldehyde [RN:R13181]

Reaction(KEGG)

R13181

Substrate

2-dehydro-3-deoxy-L-fuconate [CPD:C03827]

Product

pyruvate [CPD:C00022];
(S)-lactaldehyde [CPD:C00424]

Comment

The enzyme, characterized from the bacteria Veillonella ratti and Campylobacter jejuni, participates in an L-fucose degradation pathway. It also has significant activity with 2-dehydro-3-deoxy-D-pentonate (cf. EC 4.1.2.28, 2-dehydro-3-deoxy-D-pentonate aldolase).

History

EC 4.1.2.64 created 2023

Pathway

ec00051

Fructose and mannose metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K26911

2-dehydro-3-deoxy-L-fuconate aldolase

Genes

CJE:	Cj0481(dapA)

CJB:	BN148_0481(dapA)

CJI:	CJSA_0451(dapA)

CJS:

CJS3_0473

CJP:	A911_02350

CJEJ:

N564_00468

CJEU:

N565_00517

CJEN:

N755_00516

CJEI:

N135_00533

CJER:

H730_02985

CJY:	QZ67_00492(dapA_1)

CJQ:	UC78_0467(dapA_1)

CJW:	PJ18_02395

CJR:

CJE0532

CJD:	JJD26997_1453

CJZ:	M635_06765

CCC:	G157_06235

CCF:

YSQ_07435

CCY:

YSS_02220

CCOI:

YSU_06445

CCOF:

VC76_02535(dapA_1)

CCOO:

ATE51_03242(dapA_2)

CIS:

CINS_1514

PTHE:

LF599_00150 LF599_16950

PUF:

UFO1_3478

PFT:

JBW_00806

» show all

Reference

1 [PMID:31914410]

Authors

Watanabe S.

Title

Characterization of l-2-keto-3-deoxyfuconate aldolases in a nonphosphorylating l-fucose metabolism pathway in anaerobic bacteria.

Journal

J Biol Chem 295:1338-1349 (2020)
DOI:10.1074/jbc.RA119.011854

Sequence

[ag:WP_127057788] [cje:Cj0481]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.2.64

IUBMB Enzyme Nomenclature:

4.1.2.64

ExPASy - ENZYME nomenclature database:

4.1.2.64

BRENDA, the Enzyme Database:

4.1.2.64

All links

Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (28)   
All databases (39)   

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