KEGG   ENZYME: 4.1.2.66
Entry
EC 4.1.2.66                 Enzyme                                 
Name
4-coumarate hydratase/lyase;
4-hydroxybenzaldehyde synthase;
4HBS
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
4-coumarate acetate-lyase (4-hydroxybenzaldehyde-forming)
Reaction(IUBMB)
4-coumarate + H2O = 4-hydroxybenzaldehyde + acetate (overall reaction);
(1a) 4-coumarate + H2O = 3-hydroxy-3-(4-hydroxyphenyl)propanoate;
(1b) 3-hydroxy-3-(4-hydroxyphenyl)propanoate = 4-hydroxybenzaldehyde + acetate
Substrate
4-coumarate [CPD:C00811];
H2O [CPD:C00001];
3-hydroxy-3-(4-hydroxyphenyl)propanoate
Product
4-hydroxybenzaldehyde [CPD:C00633];
acetate [CPD:C00033];
3-hydroxy-3-(4-hydroxyphenyl)propanoate
Comment
The enzyme has been purified from vanilla pods of the orchid Vanilla planifolia. It is highly specific for 4-coumarate. Similar compounds such as cinnamate, caffeate, sinapate and o-coumarate are not substrates.
History
EC 4.1.2.66 created 2024
Reference
1  [PMID:12423881]
  Authors
Podstolski A, Havkin-Frenkel D, Malinowski J, Blount JW, Kourteva G, Dixon RA.
  Title
Unusual 4-hydroxybenzaldehyde synthase activity from tissue cultures of the vanilla orchid Vanilla planifolia.
  Journal
Phytochemistry 61:611-20 (2002)
DOI:10.1016/s0031-9422(02)00285-6
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.66
IUBMB Enzyme Nomenclature: 4.1.2.66
ExPASy - ENZYME nomenclature database: 4.1.2.66
BRENDA, the Enzyme Database: 4.1.2.66

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
All databases (4)   

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