KEGG   ENZYME: 4.1.3.22
Entry
EC 4.1.3.22                 Enzyme                                 
Name
citramalate lyase;
citramalate pyruvate-lyase;
citramalate synthase;
citramalic-condensing enzyme;
citramalate synthetase;
citramalic synthase;
(S)-citramalate lyase;
(+)-citramalate pyruvate-lyase;
citramalate pyruvate lyase;
(3S)-citramalate pyruvate-lyase;
(2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
(2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase (acetate-forming)
Reaction(IUBMB)
(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate [RN:R00325]
Reaction(KEGG)
R00325
Substrate
(2S)-2-hydroxy-2-methylbutanedioate [CPD:C02614]
Product
acetate [CPD:C00033];
pyruvate [CPD:C00022]
Comment
The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.11 (citramalate CoA-transferase) and EC 4.1.3.25 (citramalyl-CoA lyase).
History
EC 4.1.3.22 created 1972
Pathway
ec00660  C5-Branched dibasic acid metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:4301387]
  Authors
Barker HA.
  Title
Citramalate lyase of Clostridium tetanomorphum.
  Journal
Arch Mikrobiol 59:4-12 (1967)
DOI:10.1007/bf00406311
Reference
2  [PMID:923590]
  Authors
Dimroth P, Buckel W, Loyal R, Eggerer H.
  Title
Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase.
  Journal
Eur J Biochem 80:469-77 (1977)
DOI:10.1111/j.1432-1033.1977.tb11902.x
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.22
IUBMB Enzyme Nomenclature: 4.1.3.22
ExPASy - ENZYME nomenclature database: 4.1.3.22
BRENDA, the Enzyme Database: 4.1.3.22
CAS: 9027-93-4

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (8)   
   RefSeq(nuc) (2)   
   GenBank (3)   
   EMBL (3)   
All databases (19)   

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