KEGG   ENZYME: 4.1.3.45
Entry
EC 4.1.3.45                 Enzyme                                 
Name
3-hydroxybenzoate synthase;
chorismatase/3-hydroxybenzoate synthase;
hyg5 (gene name);
bra8 (gene name);
XanB2
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
chorismate pyruvate-lyase (3-hydroxybenzoate-forming)
Reaction(IUBMB)
chorismate = 3-hydroxybenzoate + pyruvate [RN:R10597]
Reaction(KEGG)
R10597
Substrate
chorismate [CPD:C00251]
Product
3-hydroxybenzoate [CPD:C00587];
pyruvate [CPD:C00022]
Comment
The enzyme, found in several bacterial species is involved in biosynthesis of secondary products. The enzyme from the bacterium Xanthomonas campestris pv. campestris also has the activity of EC 4.1.3.40, chorismate lyase [3].
History
EC 4.1.3.45 created 2013
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
Orthology
K18240  chorismate lyase / 3-hydroxybenzoate synthase
Genes
XFA: XF_0769
XFT: PD_1889(fkbO)
XFM: Xfasm12_2072
XFN: XfasM23_1994
XFF: XFLM_03915
XFL: P303_00390
XFS: D934_13290
XFH: XFHB_11425
XTW: AB672_11600
XCC: XCC4014(rapK)
XCB: XC_4103
XCA: xcc-b100_4207
XCP: XCR_0248
XCV: XCV4191
XAX: XACM_3971
XAC: XAC4103(rapK)
XCI: XCAW_00197(rapK)
XCT: J151_04282
XCJ: J158_04235
XCU: J159_04231
XCN: J169_04279
XCW: J162_04236
XCR: J163_04231
XCM: J164_04232
XCF: J172_04272
XFU: XFF4834R_chr39700(xanB2)
XAO: XAC29_20670
XOM: XOO4072(XOO4072)
XOO: XOO4322(rapK)
XOP: PXO_03739(pigB)
XOY: AZ54_02365
XOR: XOC_0424(pigB)
XOZ: BE73_22300
XAL: XALC_0126
XSA: SB85_11895
XTN: FD63_18940
XFR: BER92_01675
XVE: BJD12_11200
XPE: BJD13_18540
XHR: XJ27_14355
XGA: BI317_02115
XPH: XppCFBP6546_13945(XppCFBP6546P_13945)
XVA: C7V42_20965
XAN: AC801_20370
XAR: XB05_15580
XHY: FZ025_10110
XCZ: EBN15_01230
XTH: G4Q83_20220
XEU: XSP_003883
XHD: LMG31886_42240
XPR: MUG10_11600
XAG: HEP73_04220
XDY: NYR95_21595
XAS: HEP74_04092
SACZ: AOT14_35850
STEK: AXG53_17020
SRH: BAY15_3657
SLM: BIZ42_08875
PSU: Psesu_2797
PSUW: WQ53_09330
PSD: DSC_00450
PMEX: H4W19_12065
PDD: MNQ95_07815
PWI: MWN52_17665
LAB: LA76x_0248
LAQ: GLA29479_4083(xanB2)
LCP: LC55x_5095
LGU: LG3211_5064
LEZ: GLE_4979
LEM: LEN_0460
LMB: C9I47_0288
LYT: DWG18_12775
LUE: DCD74_10495
LYJ: FKV23_00765
LSOL: GOY17_01120
LSX: H8B22_08350
LARE: HIV01_012885
LHX: LYSHEL_11580(rapK)
LCAS: LYSCAS_11580(rapK)
LCIC: INQ41_00570
LAVI: INQ42_00570
LLZ: LYB30171_00206(rapK)
LAUX: LA521A_02670
LYA: RDV84_08500
LUM: CNR27_04035
LUS: E5843_13855
LUG: FPZ22_08045
THES: FHQ07_09135
THEH: G7079_01750
TCN: H9L16_04465
TBV: H9L17_07380
XBC: ELE36_19945
FSG: LQ771_15700
FED: LQ772_00300
RHD: R2APBS1_3770
RGL: CS053_02150
RTH: LRK53_02215
DJI: CH75_19260
DJA: HY57_04105
DTX: ATSB10_27120
DYE: EO087_10955
DCS: ISN74_19060
DTL: H8F01_09220
DTA: DYST_03258
DKO: I596_56
LRZ: BJI69_05805
LPY: FIV34_01550
LANH: KR767_08190
LFL: IM816_17450
LAEG: L2Y94_01390
LAEO: L2Y97_01455
LAES: L2Y96_01455
XBA: C7S18_22540
TAMN: N4264_03405
ALR: DS731_16695
APEL: CA267_009185
SALM: D0Y50_15440
CJA: CJA_0104(fkbO)
CEB: B0D95_12335
CEK: D0B88_05945
TTU: TERTU_3279
MARQ: MARGE09_P1022
MCA: MCA1495
METU: GNH96_09190
MMEO: OOT43_01470
MMAI: sS8_2838
MSZE: MSZNOR_3700
MMOB: F6R98_00895
MISZ: MishRS11D_00380(rapK)
THIS: HZT40_23025
TUN: J9260_13960
TLO: J9253_19325
TANI: J8380_07195
TLC: RCF98_05295
TDU: QJT80_13290
NOC: Noc_2127
NHL: Nhal_2765
NWA: Nwat_0961
NWR: E3U44_11135
TVI: Thivi_2245
NTT: TAO_1291
TSY: THSYN_02965
NTG: NSCAC_0569
THIM: KFB96_13540
HHC: M911_02890
EBS: ECTOBSL9_0369
TGR: Tgr7_0320
TKM: TK90_1054 TK90_1999
TNI: TVNIR_0102
TTI: THITH_00615
TVR: TVD_06985 TVD_10280
APRS: BI364_16220
AAEO: BJI67_01110
AFY: BW247_02255
HNA: Hneap_2236
HAZ: A9404_02390
WMA: WM2015_3004
GHL: GM160_05455
SDF: ACG33_00610
SINI: GT972_11080
FCE: JN531_006375
GBI: PG2T_05055
ACII: C4901_07725
ATY: A9R16_007130
CCAH: DWG20_05510
PSE: NH8B_1247
AQS: DKK66_12230
BUR: Bcep18194_A6087
BCH: Bcen2424_2757
BCJ: BCAL0847
BCEN: DM39_2849
BCEO: I35_2824
BAM: Bamb_2809
BAC: BamMC406_2676
BCT: GEM_0684
BCED: DM42_2314
BCEP: APZ15_01650
BPYR: ABD05_03820
BCON: NL30_26875
BDF: WI26_13300
BTEI: WS51_24135
BSEM: WJ12_13795
BPSL: WS57_32540
BSTL: BBJ41_14985
BANN: JFN94_14155
BARI: NLX30_15985
BAEN: L3V59_15805
BYI: BYI23_C009530
BUE: BRPE67_CCDS01610
BURK: DM992_06160
PPAI: E1956_39925
BUO: BRPE64_CCDS07270
TCAR: U0034_05610
VAP: Vapar_2681
VPE: Varpa_2705
VPD: VAPA_1c28650
VAA: AX767_19270
VBO: CKY39_18410
VAM: C4F17_06190
CSER: CCO03_04245
OTK: C6570_10470
OTD: J1M35_13145
HYR: BSY239_3763
HYB: Q5W_08420
HYL: LPB072_20035
HYC: E5678_13820
HPSE: HPF_20785
HTN: KI616_23100
MELA: C6568_05960
PBH: AAW51_3791
MPT: Mpe_A1331
METP: C1M51_01600
RGE: RGE_38580
RBN: RBXJA2T_00215
SNN: EWH46_12965
HAR: HEAR2873
THI: THI_2616
ETB: N7L95_07340
TBD: Tbd_2762
MEH: M301_2326
MPAU: ZMTM_13760(rapK)
SLT: Slit_0372
SIDE: SIDCL21_0299
FAM: OYT1_ch1805
SEME: MIZ01_0277
SDR: SCD_n02752
SPLB: SFPGR_17920(rapK)
SNIV: SFSGTM_28320(rapK)
SLAC: SKTS_15010
ARES: IWH25_05135
OTR: OTERR_21530
APET: ToN1_47100
DAR: Daro_4196
DEY: HYN24_15675
DDEN: KI615_21660
DECH: GBK02_01770
QAU: KI612_19805
FLE: KI610_19855
AZO: azo3920
AOA: dqs_4064
AZA: AZKH_1770
AZI: AzCIB_1917
AZD: CDA09_13435
AZR: CJ010_24600
AZQ: G3580_01750
ACOM: CEW83_15875
APP: CAP2UW1_0339
GBE: GbCGDNIH1_0917
GBH: GbCGDNIH2_0917
GBC: GbCGDNIH3_0917
GBS: GbCGDNIH4_0917
AOT: AcetOri_orf02553
BOB: GN304_00930
LCK: HN018_15380
DVN: HQ394_00740
AFR: AFE_0789
AFE: Lferr_0932
AFI: Acife_2838
AFJ: AFERRID_20270
ATX: GCD22_00281
AFP: K1Y48_07245
TCO: Theco_2590
RHER: EHE19_014580
NTP: CRH09_14150
SRC: M271_50105
SMAL: SMALA_1276
SSOI: I1A49_09865
STRM: M444_37805
SAUO: BV401_10165
SALJ: SMD11_2789
STIR: DDW44_31235
SGK: PET44_35085
SACG: FDZ84_20330 FDZ84_26815 FDZ84_28845
AMYB: BKN51_40545
SSYI: EKG83_20155
LED: BBK82_47075
ACTA: C1701_00705
PLAB: C6361_34520
PLAT: C6W10_21680
OLE: K0B96_03010
RUFI: K0V07_01920
PUO: RZN69_04390
HBS: IPV69_10830
NIO: NITINOP_0197
 » show all
Reference
1  [PMID:21383123]
  Authors
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B
  Title
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
  Journal
Proc Natl Acad Sci U S A 108:4776-81 (2011)
DOI:10.1073/pnas.1015773108
  Sequence
[src:M271_50105]
Reference
2  [PMID:23824670]
  Authors
Jiang Y, Wang H, Lu C, Ding Y, Li Y, Shen Y
  Title
Identification and characterization of the cuevaene A biosynthetic gene cluster in streptomyces sp. LZ35.
  Journal
Chembiochem 14:1468-75 (2013)
DOI:10.1002/cbic.201300316
  Sequence
[ag:AGO98693]
Reference
3  [PMID:23113660]
  Authors
Zhou L, Wang JY, Wu J, Wang J, Poplawsky A, Lin S, Zhu B, Chang C, Zhou T, Zhang LH, He YW
  Title
The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways.
  Journal
Mol Microbiol 87:80-93 (2013)
DOI:10.1111/mmi.12084
  Sequence
[xca:xcc-b100_4207]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.45
IUBMB Enzyme Nomenclature: 4.1.3.45
ExPASy - ENZYME nomenclature database: 4.1.3.45
BRENDA, the Enzyme Database: 4.1.3.45

  All links  
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (708)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (289)   
   KEGG MGENES (413)   
   RefGene (5)   
Protein sequence (35)   
   UniProt (34)   
   SWISS-PROT (1)   
DNA sequence (17)   
   GenBank (9)   
   EMBL (8)   
Protein domain (3)   
   InterPro (3)   
All databases (772)   

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