KEGG   ENZYME: 4.1.3.46
Entry
EC 4.1.3.46                 Enzyme                                 
Name
(R)-citramalyl-CoA lyase;
Ccl
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
(3R)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
Reaction(IUBMB)
(3R)-citramalyl-CoA = acetyl-CoA + pyruvate [RN:R10674]
Reaction(KEGG)
R10674
Substrate
(3R)-citramalyl-CoA [CPD:C20746]
Product
acetyl-CoA [CPD:C00024];
pyruvate [CPD:C00022]
Comment
Requires Mn2+ ions for activity. The enzyme, purified from the bacterium Chloroflexus aurantiacus, has no activity with (3S)-citramalyl-CoA (cf. EC 4.1.3.25, (S)-citramalyl-CoA lyase).
History
EC 4.1.3.46 created 2014
Orthology
K18314  (R)-citramalyl-CoA lyase
Genes
CMIC: caldi_00890(hmgL)
RXY: Rxyl_1697
RRS: RoseRS_0049
RCA: Rcas_3494
CAU: Caur_2265
CHL: Chy400_2438
CAG: Cagg_3092
STI: Sthe_0007
UAM: UABAM_05987
Reference
1  [PMID:17259315]
  Authors
Friedmann S, Alber BE, Fuchs G
  Title
Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.
  Journal
J Bacteriol 189:2906-14 (2007)
DOI:10.1128/JB.01620-06
  Sequence
[cau:Caur_2265]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.46
IUBMB Enzyme Nomenclature: 4.1.3.46
ExPASy - ENZYME nomenclature database: 4.1.3.46
BRENDA, the Enzyme Database: 4.1.3.46

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Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (9)   
Protein sequence (31)   
   UniProt (30)   
   SWISS-PROT (1)   
DNA sequence (25)   
   GenBank (12)   
   EMBL (13)   
Protein domain (3)   
   InterPro (3)   
All databases (75)   

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