KEGG   ENZYME: 4.1.99.28
Entry
EC 4.1.99.28                Enzyme                                 
Name
3'-dehydrocarminate deglycosidase;
carBC (gene names)
Class
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
Sysname
3'-dehydrocarminate lyase (kermesate-forming)
Reaction(IUBMB)
3'-dehydrocarminate = 1,5-anhydro-D-erythro-hex-1-en-3-ulose + kermesate [RN:R13184]
Reaction(KEGG)
R13184
Substrate
3'-dehydrocarminate [CPD:C22530]
Product
1,5-anhydro-D-erythro-hex-1-en-3-ulose [CPD:C22562];
kermesate [CPD:C22689]
Comment
Requires Mg2+. This enzyme, isolated from the bacterium Microbacterium 5-2b, participates in a carminate degradation pathway. Following the activity of EC 1.1.3.50, C-glycoside oxidase, it cleaves the C---C bond in 3'-dehydrocarminate. The sugar moiety is released lacking a hydroxyl at position 1, and containing a double bond between C-1 and C-2. The enzyme shows weak activity with other 3'-dehydro-C-glucosides.
History
EC 4.1.99.28 created 2023
Orthology
K26912  3'-dehydrocarminate deglycosidase
Reference
1  [PMID:34728636]
  Authors
Mori T, Kumano T, He H, Watanabe S, Senda M, Moriya T, Adachi N, Hori S, Terashita Y, Kawasaki M, Hashimoto Y, Awakawa T, Senda T, Abe I, Kobayashi M.
  Title
C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes.
  Journal
Nat Commun 12:6294 (2021)
DOI:10.1038/s41467-021-26585-1
  Sequence
[ag:BBE36491 BBE36492]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.99.28
IUBMB Enzyme Nomenclature: 4.1.99.28
ExPASy - ENZYME nomenclature database: 4.1.99.28
BRENDA, the Enzyme Database: 4.1.99.28

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
All databases (7)   

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