KEGG   ENZYME: 4.2.1.123
Entry
EC 4.2.1.123                Enzyme                                 
Name
tetrahymanol synthase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
squalene hydro-lyase (tetrahymanol-forming)
Reaction(IUBMB)
tetrahymanol = squalene + H2O [RN:R02875]
Reaction(KEGG)
R02875
Substrate
tetrahymanol [CPD:C06083]
Product
squalene [CPD:C00751];
H2O [CPD:C00001]
Comment
The reaction occurs in the reverse direction.
History
EC 4.2.1.123 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K26054  tetrahymanol synthase
Genes
TET: TTHERM_01008630
PTM: GSPATT00022597001
Reference
1  [PMID:1892870]
  Authors
Saar J, Kader JC, Poralla K, Ourisson G
  Title
Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila.
  Journal
Biochim Biophys Acta 1075:93-101 (1991)
DOI:10.1016/0304-4165(91)90080-Z
Reference
2  [PMID:15959594]
  Authors
Giner JL, Rocchetti S, Neunlist S, Rohmer M, Arigoni D
  Title
Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis.
  Journal
Chem Commun (Camb) 3089-91 (2005)
DOI:10.1039/b504300j
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.123
IUBMB Enzyme Nomenclature: 4.2.1.123
ExPASy - ENZYME nomenclature database: 4.2.1.123
BRENDA, the Enzyme Database: 4.2.1.123

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (5)   
   InterPro (5)   
All databases (19)   

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