| Entry |
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| Name |
dammarenediol II synthase;
dammarenediol synthase;
2,3-oxidosqualene (20S)-dammarenediol cyclase;
DDS;
(S)-squalene-2,3-epoxide hydro-lyase (dammarenediol-II forming)
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
(3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (dammarenediol-II-forming)
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| Reaction(IUBMB) |
dammarenediol II = (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O [RN: R09701]
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| Reaction(KEGG) |
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| Substrate |
dammarenediol II
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| Product |
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD: C01054];
H2O [CPD: C00001]
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| Comment |
The reaction occurs in the reverse direction.
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| History |
EC 4.2.1.125 created 2011
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| Pathway |
| ec00909 | Sesquiterpenoid and triterpenoid biosynthesis |
| ec00999 | Biosynthesis of various plant secondary metabolites |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K15817 | dammarenediol II synthase |
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| Reference |
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| Authors |
Tansakul P, Shibuya M, Kushiro T, Ebizuka Y |
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| Title |
Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Han JY, Kwon YS, Yang DC, Jung YR, Choi YE |
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| Title |
Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 4.2.1.125 |
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