ENZYME: 4.2.1.136 Help
Entry
Name
ADP-dependent NAD(P)H-hydrate dehydratase;
(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing);
(6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing;
NADH-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming)
Reaction(IUBMB)
(1) ADP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = AMP + phosphate + NADH [RN:
R10267 ];
(2) ADP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = AMP + phosphate + NADPH [RN:
R10268 ]
Reaction(KEGG)
Substrate
ADP [CPD:
C00008 ];
(6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide [CPD:
C04856 ];
(6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate [CPD:
C04899 ]
Product
Comment
Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers. The enzyme from bacteria consists of two domains, one of which acts as an NAD(P)H-hydrate epimerase that interconverts the two isomers to a 60:40 ratio (cf. EC
5.1.99.6 ), while the other catalyses the dehydration. Hence the enzyme can restore the complete mixture of isomers into NAD(P)H. The enzyme has no activity with ATP, contrary to the enzyme from eukaryotes (cf. EC
4.2.1.93 , ATP-dependent NAD(P)H-hydrate dehydratase).
History
EC 4.2.1.136 created 2012
Orthology
K17758 ADP-dependent NAD(P)H-hydrate dehydratase
K23997 ADP-dependent NAD(P)H-hydrate dehydratase / NAD(P)H-hydrate epimerase
Genes
ECOO : ECRM13514_5431(yjeF)
ECOH : ECRM13516_5180(yjeF)
EDJ : ECDH1ME8569_4024(yjeF)
ECOI : ECOPMV1_04631(nnr_2)
REE : electrica_04640(nnr)
RTG : NCTC13098_06717(nnr)
CLAP : NCTC11466_04098(nnr)
KIE : NCTC12125_03309(nnr)
AHN : NCTC12129_04451(nnr)
METY : MRY16398_50940(yjeF)
PSHI : SAMEA2665130_2743(nnr)
SMW : SMWW4_v1c03680(yjeF)
SFJ : SAMEA4384070_0446(nnr)
SOF : NCTC11214_01178(nnr)
TPTY : NCTC11468_03282(nnr_1)
LRI : NCTC12151_03124(nnr)
XCA : xcc-b100_1877 xcc-b100_3270
XCI : XCAW_01276 XCAW_02074
XCT : J151_01311 J151_02580
XCJ : J158_01308 J158_02570
XCU : J159_01308 J159_02568
XCN : J169_01307 J169_02577
XCW : J162_01307 J162_02569
XCR : J163_01307 J163_02564
XCM : J164_01307 J164_02566
XCF : J172_01302 J172_02571
XFU : XFF4834R_chr24190 XFF4834R_chr33680
XAO : XAC29_05900 XAC29_12210
XOM : XOO2580(XOO2580) XOO3247(XOO3247)
XOP : PXO_00413(yjeF) PXO_02084
XOY : AZ54_06565 AZ54_10470
XOZ : BE73_09925 BE73_17180
XFR : BER92_05620 BER92_12125
XVE : BJD12_03090 BJD12_19145
XPE : BJD13_04375 BJD13_10840
XHR : XJ27_05915 XJ27_09310
XGA : BI317_06855 BI317_10805
XPH : XppCFBP6546_00960(XppCFBP6546P_00960) XppCFBP6546_05700(XppCFBP6546P_05700)
XVA : C7V42_06200 C7V42_10120
XAN : AC801_05755 AC801_12385
XAR : XB05_00585 XB05_07085
XEU : XSP_001190 XSP_002420
XHD : LMG31886_18630(nnr) LMG31886_31650(nnrD)
XAG : HEP73_00677 HEP73_01797
XDY : NYR95_06520 NYR95_13030
XAS : HEP74_00652 HEP74_01715
PMEX : H4W19_04090 H4W19_06990
LAUX : LA521A_13100 LA521A_16820
LUM : CNR27_06815 CNR27_11060
FSG : LQ771_04070 LQ771_04215
FED : LQ772_10460 LQ772_10605
LAEG : L2Y94_08850 L2Y94_16665
VPL : SA104470976_03058(nnr)
PMAI : CF386_06695 CF386_06700
PAEB : NCGM1900_5695(yjeF)
PVR : PverR02_02605 PverR02_15200
PMUD : NCTC8068_00515(nnr)
PSK : U771_03000 U771_16615
PANR : A7J50_0502 A7J50_2942
PTAE : NCTC10697_04077(nnr)
PNB : NK667_10880 NK667_24550
ABD : ABTW07_1233 ABTW07_1745
SCAA : TUM17387_06190(yjeF)
LLG : 44548918_02285(yjeF)
LJR : NCTC11533_02372(yjeF)
LCJ : NCTC11976_00258(yjeF)
LWA : SAMEA4504053_3200(nnr)
LSS : NCTC12082_01488(yjeF)
LADL : NCTC12735_01531(yjeF)
MISZ : MishRS11D_15190(nnr)
THIO : AYJ59_03135 AYJ59_04105
TNI : TVNIR_2782(yjeF_[H])
MMW : Mmwyl1_1965 Mmwyl1_3063
AEL : NCTC12917_03439(nnr)
CHJ : NCTC10426_01762(nnr)
NWE : SAMEA3174300_0345(nnr_1)
NZO : SAMEA4504057_1294(nnr_1)
NCI : NCTC10296_01691(nnr_1)
NCZ : NCTC10294_00742(nnr)
NANI : NCTC12227_00675(nnr_1)
ECOR : SAMEA4412678_2034(nnr_2)
CHIC : N8I74_03535 N8I74_08530
REH : H16_A1504(h16_A1504)
BUE : BRPE67_ACDS12650(yjeF)
PLG : NCTC10937_00750(nnr)
LMIR : NCTC12852_01899(nnr)
BTRM : SAMEA390648700916(nnr_1)
AXX : ERS451415_00430(nnr_1)
AMON : H9L24_07540 H9L24_20040
VAA : AX767_03820 AX767_18800
JSV : CNX70_09190 CNX70_14840
JLV : G3257_08955 G3257_15315
JAH : JAB4_019040(nnrD) JAB4_030320(nnr)
JRI : P9875_09270 P9875_15115
MASS : CR152_24135 CR152_30695
MANC : IV454_17640 IV454_24615
MFY : HH212_00440 HH212_22155
MVAR : MasN3_18270(nnrD) MasN3_25240
MENY : LSQ66_04645 LSQ66_08710
MLIR : LPB04_18090 LPB04_21765
TCT : PX653_06910 PX653_12625
DUG : HH213_25255 HH213_27635
DZO : SR858_11935 SR858_14705
TMJ : P0M04_26960 P0M04_32600
EHB : E7V67_007460 E7V67_013650
URU : DSM104443_02389(nnr)
UPL : DSM104440_02132(nnr)
RBS : RHODOSMS8_00829(nnr)
RAD : CO657_08715 CO657_30815
TALZ : RPMA_16435 RPMA_27240
MEA : Mex_1p2375 Mex_1p5157
MZA : B2G69_05515 B2G69_19480
MRD : Mrad2831_3050 Mrad2831_5131
MAQU : Maq22A_1p31280 Maq22A_c01815
MEE : DA075_02155 DA075_32175
MIND : mvi_09470 mvi_11790(nnrD)
MTAD : M6G65_01835 M6G65_10055 M6G65_30285
MOC : BB934_01520 BB934_32080
MTUN : MTUNDRAET4_3844(nnrE)
JAV : OXU80_12745 OXU80_19435
BGOE : IFJ75_07110 IFJ75_13280
TSV : DSM104635_01949(nnr)
SPSE : SULPSESMR1_01067(nnr)
RMM : ROSMUCSMR3_00617(nnr)
AHT : ANTHELSMS3_03770(nnr)
PCON : B0A89_02085 B0A89_07795
LVS : LOKVESSMR4R_01729(nnr)
NRE : BES08_02000 BES08_25735
SPHK : SKP52_09120 SKP52_11500
SPHP : LH20_11555 LH20_15565
SMAG : AN936_07620 AN936_22270
SMAZ : LH19_07775 LH19_11705 LH19_25300
STER : AOA14_16115 AOA14_16750
SPHQ : BWQ93_02060 BWQ93_07590
SPHX : E5675_11180 E5675_15505
RDI : CMV14_15260 CMV14_15335
SPAN : AWL63_07505 AWL63_16595
SPLM : BXU08_03955 BXU08_17610
SPHC : CVN68_03915 CVN68_11140
SLUT : H9L13_04490 H9L13_07835
SRHI : H9L12_00120 H9L12_04845
SSED : H9L14_01350 H9L14_06430
SXA : FMM02_00515 FMM02_04595
SPAI : FPZ24_04325 FPZ24_08870
SPII : G7077_00415 G7077_08275
SSIN : G7078_03295 G7078_06505
SSAU : H8M03_03360 H8M03_09900
SARI : H5J25_09020 H5J25_14510
SSUA : FPZ54_01765 FPZ54_02935
SBIN : SBA_ch1_25040 SBA_ch1_27800(nnrD)
SGLC : M1K48_02550 M1K48_08480
SINB : SIDU_05700 SIDU_14945
SYB : TZ53_07700 TZ53_19155
SPMI : K663_07885 K663_14690
SPHB : EP837_00144 EP837_01163
SPHR : BSY17_229 BSY17_3257
SPHT : K426_13365 K426_22849
SHYD : CJD35_02705 CJD35_12835
SPYG : YGS_C1P0788 YGS_C1P1063
SUFL : FIL70_07895 FIL70_20460
SBAR : H5V43_05995 H5V43_17115
SPPH : KFK14_14495 KFK14_19100
SFLA : SPHFLASMR4Y_00838(nnr)
ACOB : P0Y56_00940 P0Y56_15390
SFLV : IC614_04465 IC614_10380
POQ : KZX46_01365 KZX46_15965
PMEA : KTC28_14155 KTC28_20025
RMT : IAI58_14870 IAI58_15780
LCK : HN018_11220 HN018_25315
ALI : AZOLI_1864 AZOLI_2462
ABS : AZOBR_100233 AZOBR_p220023
ABQ : ABAZ39_08445 ABAZ39_23540
ABF : AMK58_06060 AMK58_21735
ATI : AL072_07045 AL072_13875
AZT : TSH58p_02555 TSH58p_05965
AZM : DM194_07115 DM194_09150
AOZ : HUE56_12710 HUE56_14870
AARE : D3093_01035 D3093_23060
AZS : E6C72_01870 E6C72_12570
SKT : IGS68_13475 IGS68_32910
SMUC : JL100_014715 JL100_033935
SROE : JL101_010565 JL101_030890
HCL : NCTC13205_00773(nnr)
HPUL : NCTC13154_01349(nnr)
GBN : GEOBRER4_28640(yjeF)
PACE : A6070_03045 A6070_03180
DFI : AXF13_04300 AXF13_06075
DPG : DESPIGER_0330 DESPIGER_0666
DEF : CNY67_07165 CNY67_09665
DAF : Desaf_2722 Desaf_2781
DEJ : AWY79_01970 AWY79_12625
DDN : DND132_0356 DND132_2383
DSX : GD604_04945 GD604_11100
DSD : GD606_00665 GD606_07445
DOA : AXF15_00485 AXF15_09720
DPR : Despr_0462 Despr_1092
DAT : HRM2_35850 HRM2_44810
DTO : TOL2_C03400 TOL2_C10880
DOV : DSCO28_11910(yjeF) DSCO28_28400
DWD : DSCW_15500(yjeF) DSCW_27260
DALK : DSCA_14900(nnr) DSCA_25060
DLI : dnl_21720(nnr) dnl_46680
DMM : dnm_054500 dnm_058340(nnr)
DAO : Desac_0456 Desac_0729
DTI : Desti_1677 Desti_4224
DAX : FDQ92_02385 FDQ92_08665
TID : Thein_0053 Thein_1837
TOP : TOPB45_0012 TOPB45_1238
TCM : HL41_00185 HL41_03780
SCU : SCE1572_02535 SCE1572_26130
BAZ : BAMTA208_19615(yxkO)
NTM : BTDUT50_05720 BTDUT50_14640
SAUV : SAI7S6_1000060(nnrD)
SAUW : SAI5S5_1000060(nnrD)
SAUX : SAI6T6_1000060(nnrD)
SAUY : SAI8T7_1000060(nnrD)
SDP : NCTC12225_00008(nnrD)
SPIC : SAMEA4384060_0007(nnrD)
SSH : NCTC13712_00007(nnrD)
SSIM : SAMEA4384339_0007(nnrD)
SSTE : SAMEA4384403_0012(nnrD)
SMJ : SMULJ23_1411 SMULJ23_1419
SVB : NCTC12167_00645(nnrD)
SMEN : SAMEA4412692_0064(nnrD)
SFER : NCTC12278_00529(nnrD)
SCAI : NCTC12191_01257(nnrD)
SPSU : NCTC13786_00693(nnrD)
SPOC : NCTC10925_00552(nnrD)
SAUP : NCTC3168_00171(nnrD)
SURN : NCTC13766_00561(nnrD)
SVF : NCTC3166_00602(nnrD)
SMIE : NCTC11169_01326(nnrD)
ECEC : NCTC12421_00424(nnrD)
FHM : R0V13_07070 R0V13_07195
CCOH : SAMEA4530647_2214(nnr)
PFAA : MM59RIKEN_32770(nnr)
BPRO : PMF13cell1_03748(nnr)
CSCI : HDCHBGLK_02933(nnr)
CHYL : CE91St63_16950(nnr)
CBAR : PATL70BA_3289(nnrE)
EAC : EAL2_808p03930 EAL2_c09240(yjeF)
TPZ : Tph_c18570 Tph_c19240
CDIA : CaldiYA01_06570(nnr)
PHAR : NCTC13077_00121(nnr_1)
PIV : NCTC13079_01045(nnr)
VDN : NCTC11831_00850(nnr)
DHO : Dia5BBH33_13680(nnr)
PFAC : PFJ30894_02268(nnr)
ALLO : KWG61_04435 KWG61_04440
FIT : Fi14EGH31_23160(nnr)
SCR : SCHRY_v1c06620(yxkO)
SSYR : SSYRP_v1c06840(yxkO)
PCAT : Pcatena_14910(yjeF)
MMAE : MMARE11_10750 MMARE11_42880
MLI : MULP_01249 MULP_04690
MPSE : MPSD_12580 MPSD_46210
MSHO : MSHO_02660 MSHO_29450
MBAI : MB901379_00982(nnr)
MHEK : JMUB5695_03799(nnr)
MMEH : M5I08_01650 M5I08_08080
MKY : IWGMT90018_11120(nnr)
MPHL : MPHLCCUG_01427(nnr)
MAUU : NCTC10437_01202(nnr)
MFLV : NCTC10271_04016(nnr)
MSAL : DSM43276_03536(nnr)
CDIP : ERS451417_02329(nnr)
CHN : A605_07765 A605_13610
CMIN : NCTC10288_00109(nnr)
CCYS : SAMEA4530656_2732(nnr)
CAQM : CAQUA_11060(nnr1) CAQUA_11130(nnr2)
NFR : ERS450000_01930(nnr_1) ERS450000_03236(nnr_2)
NCY : NOCYR_0931 NOCYR_5036
NNO : NONO_c10080 NONO_c59670
NAD : NCTC11293_01699(nnr)
NWL : NWFMUON74_43680 NWFMUON74_62940
RCR : NCTC10994_03776(nnr)
DKN : NHB83_03890 NHB83_06415
SLE : sle_29240(sle_29240)
SXT : KPP03845_104537(nnr)
LEIF : HF024_05520 HF024_09845
CMH : VO01_05590 VO01_15015
CCAP : AES38_06255 AES38_14215
CZH : H9X71_06295 H9X71_09700 H9X71_14475
CCAF : FGD68_01850 FGD68_09010
RTN : A6122_0221 A6122_1871
RFS : C1I64_02680 C1I64_15560
AMAU : DSM26151_09730(carKD) DSM26151_27450(nnr)
CPHY : B5808_10585 B5808_12355
MALK : MalAC0309_1898(nnrD)
HUM : DVJ78_08590 DVJ78_10360
HEH : L3i23_12150(nnrD) L3i23_13920
FRN : F1C15_12655 F1C15_15035
PSEV : USB125703_01544(nnr)
NAEI : GCM126_02050 GCM126_29840(nnrD)
ARR : ARUE_c09020 ARUE_c30490
ARZ : AUT26_03980 AUT26_14230
ARU : ASPU41_00550 ASPU41_06695
ARQ : BWQ92_14755 BWQ92_16825
ARN : CGK93_04930 CGK93_16555
ARX : ARZXY2_3093 ARZXY2_781
ARTH : C3B78_13945 C3B78_15880
AAGI : NCTC2676_1_02268(nnr)
AJG : KKR91_13295 KKR91_14590
ASUN : KG104_14195 KG104_15450
ACAO : NF551_12580 NF551_13640
AZH : MUK71_12545 MUK71_13585
AGEG : MUG94_13585 MUG94_14710
AOD : Q8Z05_01410 Q8Z05_08660
AKO : N9A08_12105 N9A08_13480
AZX : N2K95_12480 N2K95_13445
AJR : N2K98_13185 N2K98_14190
PUE : FV140_04760 FV140_15825
PNV : JMY29_04315 JMY29_13935
APN : Asphe3_27510 Asphe3_31630
PDEL : JCQ34_13230 JCQ34_15355
POK : SMD14_14190 SMD14_16080
CGA : Celgi_0867 Celgi_1558
CEZ : CBP52_08420 CBP52_09190
CELH : GXP71_09135 GXP71_11120
CIRA : LFM56_04970 LFM56_11680
CPAL : F1D97_15120 F1D97_15905
CDON : KKR89_06335 KKR89_12915
CWAN : KG103_06580 KG103_13130
CWN : NP075_06565 NP075_13580
CXIE : NP048_06460 NP048_13175
ICA : Intca_1003 Intca_1741
ARS : ADJ73_00320 ADJ73_04390
JME : EEW87_016225 EEW87_17430
TED : U5C87_10310 U5C87_17125
DCO : SAMEA4475696_2142(nnr)
GYU : FE374_02125 FE374_15570
PAUS : NCTC13651_00809(nnr)
TFL : RPIT_02885 RPIT_10075
TEZ : BKM78_04275 BKM78_11985
TLA : TLA_TLA_00870(nnr) TLA_TLA_02415(nnrD)
BRT : J4N02_02655 J4N02_06015
NSN : EXE58_03835 EXE58_08995
NMES : H9L09_12665 H9L09_20780
NAQU : ENKNEFLB_01114(nnr)
NPS : KRR39_02025 KRR39_15530
NFC : KG111_06400 KG111_14810
AWN : NQV15_01890 NQV15_14890
ACTW : F7P10_13050 F7P10_25350
BLAP : MVA48_17190 MVA48_19320
MMAR : MODMU_4872 MODMU_5334
SACG : FDZ84_08650 FDZ84_11665
AACD : LWP59_03370 LWP59_06150
APRT : MUY14_06545 MUY14_33110
PSEE : FRP1_02040 FRP1_02775
PSEQ : AD006_09660 AD006_10390
PECQ : AD017_17490 AD017_18220
ACAD : UA74_15785 UA74_27985
MAU : Micau_3461 Micau_5450
MICB : MicB006_2515 MicB006_4459
MTUA : CSH63_07740 CSH63_30215
MTEM : GCE86_13275 GCE86_21805
MCAB : HXZ27_18310 HXZ27_27275
MSAG : GCM10017556_17060 GCM10017556_54000(nnrD)
MCHL : PVK74_07555 PVK74_17415
MFEU : H1D33_02645 H1D33_22890
MPRN : Q3V37_10725 Q3V37_22715
MHAW : RMN56_15640 RMN56_24570
AMS : AMIS_61340 AMIS_6650
ACTN : L083_0989 L083_5853
ACTS : ACWT_0726 ACWT_3899
AIH : Aiant_03820(nnrD) Aiant_50050
ACTR : Asp14428_37890 Asp14428_72870(nnrD)
ASIC : Q0Z83_081370 Q0Z83_108600
AOU : ACTOB_000679 ACTOB_005302
PSUU : Psuf_041120 Psuf_041130
CATI : CS0771_06550 CS0771_58240(nnrD)
DVC : Dvina_33485 Dvina_49575
DROS : Drose_11160 Drose_33930
DAUR : Daura_11745 Daura_47850
DMAT : Dmats_28410 Dmats_44185
CCAZ : COUCH_13815 COUCH_34945
TBW : NCTC13354_00501(nnr)
AHW : NCTC11636_01078(nnr)
AIR : NCTC12972_01396(nnr)
ASLA : NCTC11923_01084(nnr)
AVC : NCTC10951_02939(nnr)
BALA : DSM104299_04320(nnr)
SBAE : DSM104329_04095(nnr)
SYY : SYNGTS_1736(sll1433)
SYT : SYNGTI_1736(sll1433)
SYS : SYNPCCN_1735(sll1433)
SYQ : SYNPCCP_1735(sll1433)
LET : O77CONTIG1_02595(nnr)
SYP : SYNPCC7002_A0648(yjeF)
SYNN : NIES970_00810(yjeF)
NSPH : BDGGKGIB_03840(nnr)
AMOB : HG15A2_39880(nnr_1) HG15A2_40340
TRC : DYE49_00665 DYE49_12225
BTHO : Btheta7330_03716(nnr)
BCEL : BcellWH2_04158(nnr)
PCRE : NCTC12858_00269(nnr)
PCAG : NCTC12856_00816(nnr)
POC : NCTC13071_02332(nnr)
SDJ : NCTC13534_01994(nnr_2)
STHA : NCTC11429_04962(nnr)
AALG : AREALGSMS7_02876(nnr)
KOS : KORDIASMS9_04256(nnr)
CGLE : NCTC11432_05311(nnr)
CTAI : NCTC12078_01147(nnr)
CJG : NCTC13459_03113(nnr)
CANT : NCTC13489_02929(nnr)
PTAN : CRYO30217_01964(nnr)
HRR : HZS55_10090 HZS55_16255
HPEL : HZS54_15070 HZS54_18995
HSAL : JMJ58_14400 JMJ58_16590
HAKZ : J0X25_00525 J0X25_02225
NMG : Nmag_0518(nnrDE) Nmag_1014(nnrD)
HXA : Halxa_2206 Halxa_2753
NPE : Natpe_1067 Natpe_1209
NVR : FEJ81_05570 FEJ81_06355
NAY : HYG81_03880 HYG81_05130
HALY : HYG82_06550 HYG82_07150
HJT : DVR14_14645 DVR14_15240
NGE : Natgr_0374 Natgr_3571
NOU : Natoc_1364 Natoc_1933
HLC : CHINAEXTREME08605 CHINAEXTREME12615
NAJ : B1756_01270 B1756_03210
HDA : BB347_08030 BB347_09655
TVO : TVG0137051(TVG0137051)
CCAI : NAS2_0498 NAS2_1254
» show all
Taxonomy
Reference
Authors
Marbaix AY, Noel G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL
Title
Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.136