KEGG   ENZYME: 4.2.1.143
Entry
EC 4.2.1.143                Enzyme                                 
Name
versicolorin B synthase;
versiconal cyclase;
VBS
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
versiconal hydro-lyase (versicolorin-B-forming)
Reaction(IUBMB)
versiconal = versicolorin B + H2O [RN:R10402]
Reaction(KEGG)
R10402
Substrate
versiconal [CPD:C20507]
Product
versicolorin B [CPD:C20575];
H2O [CPD:C00001]
Comment
Isolated from the aflatoxin-producing mold Aspergillus parasiticus. Involved in aflatoxin biosynthesis.
History
EC 4.2.1.143 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17646  5'-oxoaverantin cyclase / versicolorin B synthase
Genes
PAN: PODANSg8556
PBEL: QC761_207270
PPSD: QC762_207270
PPSP: QC763_207270
PPSA: QC764_207270
PGRI: PgNI_01190
CHIG: CH63R_13456
ANI: ANIA_07812
AOR: AO090026000028
AFV: AFLA_006289
APUU: APUU_20052S
FFU: CLAFUR5_14272
CBET: CB0940_03000
 » show all
Reference
1  [PMID:1731640]
  Authors
Lin BK, Anderson JA
  Title
Purification and properties of versiconal cyclase from Aspergillus parasiticus.
  Journal
Arch Biochem Biophys 293:67-70 (1992)
DOI:10.1016/0003-9861(92)90366-5
  Sequence
[ag:AAC49318]
Reference
2  [PMID:8784203]
  Authors
McGuire SM, Silva JC, Casillas EG, Townsend CA
  Title
Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis of the stereodifferentiating cyclization in aflatoxin biosynthesis essential to DNA interaction.
  Journal
Biochemistry 35:11470-86 (1996)
DOI:10.1021/bi960924s
  Sequence
[ag:AAC49318]
Reference
3  [PMID:8662689]
  Authors
Silva JC, Minto RE, Barry CE 3rd, Holland KA, Townsend CA
  Title
Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Expansion of the aflatoxin b1 biosynthetic gene cluster.
  Journal
J Biol Chem 271:13600-8 (1996)
DOI:10.1074/jbc.271.23.13600
  Sequence
[ag:AAC49318]
Reference
4  [PMID:8995367]
  Authors
Silva JC, Townsend CA
  Title
Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus parasiticus. A key enzyme in the aflatoxin B1 biosynthetic pathway.
  Journal
J Biol Chem 272:804-13 (1997)
DOI:10.1074/jbc.272.2.804
  Sequence
[ag:AAC49318]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.143
IUBMB Enzyme Nomenclature: 4.2.1.143
ExPASy - ENZYME nomenclature database: 4.2.1.143
BRENDA, the Enzyme Database: 4.2.1.143

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (14)   
Protein sequence (8)   
   UniProt (4)   
   SWISS-PROT (4)   
Protein domain (5)   
   InterPro (5)   
All databases (40)   

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