KEGG ENZYME: 4.2.1.145

ENZYME: 4.2.1.145

Entry

EC 4.2.1.145                Enzyme

Name

capreomycidine synthase;
VioD (ambiguous)

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

(2S,3S)-3-hydroxyarginine hydro-lyase (cyclizing, (2S,3R)-capreomycidine-forming)

Reaction(IUBMB)

(2S,3S)-3-hydroxyarginine = (2S,3R)-capreomycidine + H2O [RN:R09364]

Reaction(KEGG)

R09364

Substrate

(2S,3S)-3-hydroxyarginine [CPD:C18473]

Product

(2S,3R)-capreomycidine [CPD:C18472];
H2O [CPD:C00001]

Comment

A pyridoxal 5'-phosphate protein. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin.

History

EC 4.2.1.145 created 2013

Orthology

K20615

capreomycidine synthase

Genes

SCAL:

I6J39_31735(vioD)

Reference

1 [PMID:15368581]

Authors

Yin X, McPhail KL, Kim KJ, Zabriskie TM

Title

Formation of the nonproteinogenic amino acid 2S,3R-capreomycidine by VioD from the viomycin biosynthesis pathway.

Journal

Chembiochem 5:1278-81 (2004)
DOI:10.1002/cbic.200400187

Reference

2 [PMID:15368582]

Authors

Ju J, Ozanick SG, Shen B, Thomas MG

Title

Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861.

Journal

Chembiochem 5:1281-5 (2004)
DOI:10.1002/cbic.200400136

Sequence

[ag:AAP92494]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.145

IUBMB Enzyme Nomenclature:

4.2.1.145

ExPASy - ENZYME nomenclature database:

4.2.1.145

BRENDA, the Enzyme Database:

4.2.1.145

DBGET integrated database retrieval system