KEGG ENZYME: 4.2.1.146

ENZYME: 4.2.1.146

Entry

EC 4.2.1.146                Enzyme

Name

L-galactonate dehydratase;
LGD1

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

L-galactonate hydro-lyase (2-dehydro-3-deoxy-L-galactonate-forming)

Reaction(IUBMB)

L-galactonate = 2-dehydro-3-deoxy-L-galactonate + H2O [RN:R10532]

Reaction(KEGG)

R10532

Substrate

L-galactonate [CPD:C15930]

Product

2-dehydro-3-deoxy-L-galactonate [CPD:C20680];
H2O [CPD:C00001]

Comment

The enzyme takes part in a D-galacturonate degradation pathway in the fungi Trichoderma reesei (Hypocrea jecorina) and Aspergillus niger.

History

EC 4.2.1.146 created 2013

Pathway

ec00040

Pentose and glucuronate interconversions

ec01100

Metabolic pathways

Orthology

K18102

L-galactonate dehydratase

Genes

PPA:	PAS_chr4_0572

PGU:	PGUG_05189

CTEN:

CANTEDRAFT_135663

SLB:	AWJ20_3253 AWJ20_3295

NCR:

NCU07064

NTE:	NEUTE1DRAFT131658(NEUTE1DRAFT_131658)

SMP:	SMAC_03881

PAN:	PODANSg3017

PBEL:

QC761_408390(LGD1)

PPSD:

QC762_408390(LGD1)

PPSP:

QC763_408390(LGD1)

PPSA:

QC764_408390(LGD1)

TTT:	THITE_2153466

MTM:	MYCTH_2064932 MYCTH_82505

CTHR:

CTHT_0042160

MGR:

MGG_01300

PPEI:

PpBr36_00810

PGRI:

PgNI_04224

TMN:	UCRPA7_2751 UCRPA7_4700

SSCK:

SPSK_00800 SPSK_03340 SPSK_06299

FGR:	FGSG_09257

FPU:	FPSE_09649

FPOA:

FPOAC1_012439(LGD1)

FVN:	FVRRES_13523

FVR:	FVEG_03852 FVEG_12512 FVEG_12549

FOX:	FOXG_05984 FOXG_15221 FOXG_17432

NHE:	NECHADRAFT_56323 NECHADRAFT_66837

FFC:	NCS54_00305100 NCS54_00875300

FKR:	NCS57_00300500 NCS57_01447900

FMU:	J7337_003423(LGD1_1) J7337_003862(LGD1_2) J7337_007844

TRE:	TRIREDRAFT_104599 TRIREDRAFT_66662

TRR:	M419DRAFT_11053 M419DRAFT_73300

MAW:

MAC_03404

MAJ:

MAA_02004

PCHM:

VFPPC_09660 VFPPC_10154 VFPPC_14026 VFPPC_15420

CMT:

CCM_00320

AMUS:

LMH87_000566

PLJ:	VFPFJ_04113 VFPFJ_07689

PTKZ:

JDV02_004411(LGD1)

VAL:	VDBG_08188

VDA:	VDAG_10081

CFJ:	CFIO01_10120

CLUP:

CLUP02_16470

CHIG:

CH63R_14134

SAPO:

SAPIO_CDS5438 SAPIO_CDS6402

ELA:	UCREL1_8211

PFY:	PFICI_14149

SSL:	SS1G_12905

BFU:	BCIN_01g09450(Bclgd1)

MBE:

MBM_09691

PSCO:

LY89DRAFT_610683

GLZ:	GLAREA_00035

ANI:	ANIA_06035

AFM:	AFUA_2G09810

ACT:	ACLA_068890

NFI:	NFIA_085260

AOR:	AO090011000654

ANG:	An16g05390

AFV:	AFLA_008058

ALUC:

AKAW2_70451A(LGD1)

ACHE:

ACHE_40955S(LGD1)

APUU:

APUU_11124A(LGD1)

PCS:	N7525_004390 N7525_011616

PDP:	PDIP_64950

POU:	POX_f07869

TMF:	EYB26_004761

TRG:	TRUGW13939_01876 TRUGW13939_04485

ABE:

ARB_05174

TVE:

TRV_03587

PNO:	SNOG_13604

PTE:

PTT_15544

BZE:	COCCADRAFT_3106

BSC:	COCSADRAFT_180831

BOR:	COCMIDRAFT_2503

AALT:

CC77DRAFT_1017550

ARAB:

EKO05_0010953

ZTR:	MYCGRDRAFT_71623

PFJ:	MYCFIDRAFT_37783

FFU:	CLAFUR5_08447

CBET:

CB0940_04302

BCOM:

BAUCODRAFT_37158

NPA:	UCRNP2_9857

TML:	GSTUM_00012245001

TMS:	TREMEDRAFT_30567 TREMEDRAFT_58672

TASA:

A1Q1_01111

» show all

Reference

1 [PMID:16879654]

Authors

Kuorelahti S, Jouhten P, Maaheimo H, Penttila M, Richard P

Title

L-galactonate dehydratase is part of the fungal path for D-galacturonic acid catabolism.

Journal

Mol Microbiol 61:1060-8 (2006)
DOI:10.1111/j.1365-2958.2006.05294.x

Sequence

[tre:TRIREDRAFT_104599]

Reference

2 [PMID:18768163]

Authors

Martens-Uzunova ES, Schaap PJ

Title

An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.

Journal

Fungal Genet Biol 45:1449-57 (2008)
DOI:10.1016/j.fgb.2008.08.002

Sequence

[ang:An16g05390]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.146

IUBMB Enzyme Nomenclature:

4.2.1.146

ExPASy - ENZYME nomenclature database:

4.2.1.146

BRENDA, the Enzyme Database:

4.2.1.146

DBGET integrated database retrieval system