| Entry |
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| Name |
tetracenomycin F2 cyclase;
tcmI (gene name)
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
tetracenomycin F2 hydro-lyase (tetracenomycin-F1-forming)
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| Reaction(IUBMB) |
tetracenomycin F2 = tetracenomycin F1 + H2O [RN: R06699]
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| Reaction(KEGG) |
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| Substrate |
tetracenomycin F2 [CPD: C12366]
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| Product |
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| Comment |
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
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| History |
EC 4.2.1.154 created 2014
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| Pathway |
| ec01057 | Biosynthesis of type II polyketide products |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K15968 | tetracenomycin F2 cyclase |
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| Genes |
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| Reference |
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| Authors |
Shen B, Hutchinson CR |
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| Title |
Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Thompson TB, Katayama K, Watanabe K, Hutchinson CR, Rayment I |
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| Title |
Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 4.2.1.154 |
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