KEGG ENZYME: 4.2.1.160

ENZYME: 4.2.1.160

Entry

EC 4.2.1.160                Enzyme

Name

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one cyclohydrolase

Reaction(IUBMB)

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one = 7,8-dihydroneopterin 3'-phosphate + H2O [RN:R11072]

Reaction(KEGG)

R11072

Substrate

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C01304]

Product

7,8-dihydroneopterin 3'-phosphate [CPD:C05925];
H2O [CPD:C00001]

Comment

The enzyme participates in a folate biosynthesis pathway in Chlamydia.

History

EC 4.2.1.160 created 2015

Pathway

ec00790

Folate biosynthesis

ec01100

Metabolic pathways

Orthology

K22100

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase

Genes

CTR:	CT_327(trpC)

CTD:	CTDEC_0327(trpC)

CTF:	CTDLC_0327(trpC)

CTRD:

SOTOND1_00344

CTRO:

SOTOND5_00341

CTRT:

SOTOND6_00341

CTA:	CTA_0354(trpC)

CTY:	CTR_3231(trpC)

CRA:

CTO_0354

CTRQ:

A363_00348

CTRX:

A5291_00347

CTRZ:

A7249_00347

CTRP:

L11322_00337

CTLJ:

L1115_00337

CTLX:

L1224_00337

CTLL:

L1440_00339

CTB:	CTL0581(trpC)

CTRR:

L225667R_00338

CTLF:

CTLFINAL_03030

CTLI:

CTLINITIAL_03025

CTL:	CTLon_0577(trpC)

CTRU:

L2BUCH2_00336

CTRL:

L2BLST_00336

CTRV:

L2BCV204_00336

CTRM:

L2BAMS1_00336

CTLA:

L2BAMS2_00336

CTLM:

L2BAMS3_00336

CTLS:

L2BAMS4_00337

CTLZ:

L2BAMS5_00337

CTLC:

L2BCAN1_00338

CTLN:

L2BCAN2_00337

CTLB:

L2B795_00337

CTLQ:

L2B8200_00336

CTO:

CTL2C_17

CTRN:

L3404_00337

CTJ:	JALI_3231(trpC)

CTZ:	CTB_3231(trpC)

CTG:	E11023_01700

CTK:	E150_01710

CSW:	SW2_3301(trpC)

CES:	ESW3_3301(trpC)

CTRB:

BOUR_00345

CTRE:

SOTONE4_00341

CTRS:

SOTONE8_00347

CTEC:

EC599_3351(trpC)

CFS:	FSW4_3301(trpC)

CFW:	FSW5_3301(trpC)

CTFW:

SWFP_3511(trpC)

CTRF:

SOTONF3_00342

CTCH:

O173_01780

CTN:	G11074_01675

CTQ:	G11222_01680

CTV:	CTG9301_01675

CTW:	G9768_01675

CTRG:

SOTONG1_00342

CTRI:

BN197_3281(trpC)

CTRA:

BN442_3281(trpC)

CTRH:

SOTONIA1_00343

CTRJ:

SOTONIA3_00343

CTRK:

SOTONK1_00341

CTJT:

CTJTET1_01695

CTCF:

CTRC69_01715

CTFS:

CTRC342_01730

CTHF:

CTRC852_01735

CTCJ:

CTRC943_01685

CTHJ:

CTRC953_01680

CTMJ:

CTRC966_01690

CTTJ:

CTRC971_01680

CTJS:

CTRC122_01715

CTRC:

CTRC55_01695

CTRW:

CTRC3_01715

CTRY:

CTRC46_01695

CTCT:

CTW3_01780

CMU:	TC_0603(trpF)

CMUR:

Y015_03180

CMN:	BB17_03230

CMM:	NC80_03040

CMG:	NC81_03055

CMX:

DNC_03060

CMZ:

TAC_03180

CPM:	G5S_1085(trpF)

CPEC:

CPE3_0675(trpF)

CPEO:

CPE1_0674(trpF)

CPER:

CPE2_0675(trpF)

CFE:	CF0437(trpF)

CSUI:

Chls_650(trpC)

SNG:	SNE_A10200(tRPF)

» show all

Reference

1 [PMID:25006229]

Authors

Adams NE, Thiaville JJ, Proestos J, Juarez-Vazquez AL, McCoy AJ, Barona-Gomez F, Iwata-Reuyl D, de Crecy-Lagard V, Maurelli AT

Title

Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species.

Journal

MBio 5:e01378-14 (2014)
DOI:10.1128/mBio.01378-14

Sequence

[ctb:CTL0581]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.160

IUBMB Enzyme Nomenclature:

4.2.1.160

ExPASy - ENZYME nomenclature database:

4.2.1.160

BRENDA, the Enzyme Database:

4.2.1.160

All links

Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (88)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (87)   
All databases (98)   

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