KEGG ENZYME: 4.2.1.161

ENZYME: 4.2.1.161

Entry

EC 4.2.1.161                Enzyme

Name

bisanhydrobacterioruberin hydratase;
CruF;
C50 carotenoid 2'',3''-hydratase

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

bacterioruberin hydro-lyase (bisanhydrobacterioruberin-forming)

Reaction(IUBMB)

bacterioruberin = bisanhydrobacterioruberin + 2 H2O (overall reaction) [RN:R12710];
(1a) bacterioruberin = monoanhydrobacterioruberin + H2O [RN:R12711];
(1b) monoanhydrobacterioruberin = bisanhydrobacterioruberin + H2O [RN:R12712]

Reaction(KEGG)

R12710 R12711 R12712

Substrate

bacterioruberin [CPD:C22349];
monoanhydrobacterioruberin [CPD:C22348]

Product

bisanhydrobacterioruberin [CPD:C22347];
H2O [CPD:C00001];
monoanhydrobacterioruberin [CPD:C22348]

Comment

The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the introduction of hydroxyl groups to C3'' and C3''' of bisanhydrobacterioruberin to generate bacterioruberin.

History

EC 4.2.1.161 created 2015

Pathway

ec00906

Carotenoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K08977

bisanhydrobacterioruberin hydratase

Genes

RMAR:

GBA65_05160

MTH:

MTH_1810

MMG:	MTBMA_c03800

MWO:	MWSIV6_0343(cruF)

METC:

MTCT_1650

METE:

tca_01748

METK:

FVF72_02650

MTHM:

FZP57_01595

METJ:

FZP68_06610

MEME:

HYG87_08520

MZH:	Mzhil_0945

MEM:	Memar_0115

MFK:	E2N92_05460

HAL:

VNG_1681C

HSL:

OE_3377R

HANR:

LJ422_06790

HDL:	HALDL1_13220

HHB:

Hhub_3182

HAGS:

JT689_08120

HABO:

JRZ79_06535

HNO:	LT974_11785

HLU:	LT972_03125

HALH:

HTSR_0320

HHSR:

HSR6_0306

HSU:	HLASF_0238

HSF:	HLASA_0238

HAHS:

HSRCO_0375

SALR:

FQU85_06795

HALR:

EFA46_012290

HJE:	HacjB3_05930

HDO:	MUK72_08400

HALX:

M0R89_12780

HAXZ:

M0R88_12945

HAYC:

NGM10_02420

HAXY:

NGM07_00970

SALI:

L593_04755

SAIM:

K0C01_06240

HARA:

AArcS_2864

HMA:

rrnAC0318

HHI:

HAH_1056

HHN:	HISP_05425

HAB:	SG26_13095

HTA:	BVU17_05170

HALJ:

G9465_16505

HSIN:

KDQ40_08210

NPH:	NP_4768A(cruF)

NMO:

Nmlp_3028

NHO:	HWV23_16735

NSAL:

HWV07_18235

HUT:

Huta_2375

HTI:

HTIA_2108

HALA:

Hrd1104_01375

HASV:

SVXHr_2181(cruF)

HABN:

HBNXHr_2177(cruF)

HMU:

Hmuk_1362

HALZ:

E5139_09970

HALL:

LC1Hm_0583

HAZP:

GBQ70_09965

HALI:

BV210_13225

HSN:	DV733_06785

HDS:	HSR122_2628

HRR:	HZS55_20275

HPEL:

HZS54_23760

HLT:	I7X12_14760

HARC:

HARCEL1_04570

SSAI:

N0B31_09230

HAAD:

MW046_14470

HWA:	HQ_2861A(cruF)

HWC:	Hqrw_3255(cruF)

HVO:

HVO_2526

HME:

HFX_2548

HGI:	ABY42_12660

HALE:

G3A49_16055

HLS:	KU306_00330

HLN:	SVXHx_2074(cruf)

HBO:	Hbor_10670

HAQ:	DU484_15080

HAJ:	DU500_15110

HAER:

DU502_13070

HRA:	EI982_16635

HLM:	DV707_06365

HALM:

FCF25_03140

HLA:

Hlac_1899

HALP:

DOS48_09175

HALB:

EKH57_01640

HEZZ:

EO776_09990

HALQ:

Hrr1229_010275

HSS:	J7656_06545

HSAI:

HPS36_12065

HAZZ:

KI388_07980

SRUB:

C2R22_15230

HAE:	halTADL_0467

HALN:

B4589_011170

HALG:

HUG10_00785

HALU:

HUG12_16795

HMP:	K6T50_14395

HRE:	K6T36_14345

HRM:	K6T25_02460

HACB:

Hbl1158_06190

HDF:	AArcSl_1203(cruF)

HAH:	Halar_2117

HTU:

Htur_2702

HSAL:

JMJ58_15360

HAKZ:

J0X25_02305

NMG:

Nmag_1003

HXA:	Halxa_2220

NAT:

NJ7G_1610

NPE:	Natpe_1079

NPL:	FGF80_05285

NAY:	HYG81_05190

HALY:

HYG82_06620

HJT:	DVR14_14695

HLO:	J0X27_13910

NGE:	Natgr_2202

HRU:	Halru_1197

SAWL:

NGM29_09960

HALV:

NGM15_02165

NOU:	Natoc_1919

HLR:	HALLA_16015

HLC:	CHINAEXTREME08685

NAJ:	B1756_18795

NAG:	AArcMg_2865

NAN:	AArc1_0838

NARA:

QQ977_09760(cruF)

NBG:	DV706_10175

NAS:	GCU68_01900

HDA:	BB347_09715

NAC:	AQV86_03665

» show all

Reference

1 [PMID:25712483]

Authors

Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S

Title

Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.

Journal

J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14

Sequence

[ag:BAP82511]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.161

IUBMB Enzyme Nomenclature:

4.2.1.161

ExPASy - ENZYME nomenclature database:

4.2.1.161

BRENDA, the Enzyme Database:

4.2.1.161

DBGET integrated database retrieval system