Entry
Name
(R)-2-hydroxyglutaryl-CoA dehydratase;
hgdAB (gene names)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(R)-2-hydroxyglutaryl-CoA hydro-lyase ((E)-glutaconyl-CoA-forming)
Reaction(IUBMB)
(R)-2-hydroxyglutaryl-CoA = (E)-glutaconyl-CoA + H2O
Substrate
(R)-2-hydroxyglutaryl-CoA
Product
Comment
The enzymes from the bacteria Acidaminococcus fermentans and Clostridium symbiosum are involved in the fermentation of L-glutamate. The enzyme contains [4Fe-4S] clusters, FMNH2 and riboflavin. It must be activated by an activator protein. Once activated, it can catalyse many turnovers.
History
EC 4.2.1.167 created 2016
Orthology
K20903 (R)-2-hydroxyglutaryl-CoA dehydratase subunit alpha
K20904 (R)-2-hydroxyglutaryl-CoA dehydratase subunit beta
Genes
PMIB : BB2000_2634 BB2000_2635
PVL : AOB99_14455 AOB99_14460
PVG : CRN77_06465 CRN77_06470
PHAU : PH4a_04695 PH4a_04700
CLO : HMPREF0868_0586(fldB) HMPREF0868_0587
OVA : OBV_10880(hgdA) OBV_10890(hgdB)
LASA : L9O85_09810 L9O85_09815
CAPR : EQM14_01980 EQM14_01985 EQM14_12230 EQM14_12235
CFEM : HCR03_03845 HCR03_18565 HCR03_18570
BPRM : CL3_21520 CL3_21530
BPRS : CK3_23970 CK3_23980
CSH : Closa_3010 Closa_3011
STOM : QU660_01205(hgdA) QU660_01210(hgdB)
LBW : C3V36_10445 C3V36_10450
MDV : C5Q96_01395 C5Q96_01400
FAA : HMPREF0389_01473(fldB) HMPREF0389_01474(hgdB)
PED : ING2D1G_1419(hgdB) ING2D1G_1420(hgdA)
PHAR : NCTC13077_00178(hgdA) NCTC13077_00179(hgdB)
PIV : NCTC13079_00076(hgdA)
PEQU : O6R05_08065 O6R05_08070
AFN : Acfer_1814 Acfer_1815
EYY : EGYY_07620 EGYY_07630
TRM : JO41_09910 JO41_09915
TPHG : FUT81_01930 FUT81_01935
TRZ : GWP43_09945 GWP43_09950
TMED : DWB79_07275 DWB79_07280
TRP : ABH09_09160 ABH09_09165
FNC : HMPREF0946_01476 HMPREF0946_01477
FNT : HMPREF0405_01483 HMPREF0405_01484
FUS : HMPREF0409_01242 HMPREF0409_01243
FNE : FSDG_02110 FSDG_02111
FHW : RN87_11175 RN87_11180
FPD : CTM68_10300 CTM68_10305
FGO : C4N16_07315 C4N16_07320
FNF : BSQ88_06930 BSQ88_06935
FPEI : C4N17_03520 C4N17_03525
FCI : I6I83_03795 I6I83_03800
FPOL : ERS445057_00635(hgdA) ERS445057_00636(hgdB)
» show all
Taxonomy
Reference
Authors
Buckel W
Title
The reversible dehydration of (R)-2-hydroxyglutarate to (E)-glutaconate.
Journal
Reference
Authors
Schweiger G, Dutscho R, Buckel W
Title
Purification of 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans. An iron-sulfur protein.
Journal
Sequence
Reference
Authors
Muller U, Buckel W
Title
Activation of (R)-2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans.
Journal
Reference
Authors
Hans M, Sievers J, Muller U, Bill E, Vorholt JA, Linder D, Buckel W
Title
2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum.
Journal
Sequence
Reference
Authors
Locher KP, Hans M, Yeh AP, Schmid B, Buckel W, Rees DC
Title
Crystal structure of the Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase component A.
Journal
Reference
Authors
Parthasarathy A, Pierik AJ, Kahnt J, Zelder O, Buckel W
Title
Substrate specificity of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum: toward a bio-based production of adipic acid.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.167