KEGG   ENZYME: 4.2.1.173
Entry
EC 4.2.1.173                Enzyme                                 
Name
ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase;
SmCPS4
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
geranylgeranyl-diphosphate hydro-lyase (ent-8alpha-hydroxylabd-13-en-15-yl diphosphate-forming)
Reaction(IUBMB)
ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = geranylgeranyl diphosphate + H2O [RN:R11820]
Reaction(KEGG)
R11820
Substrate
ent-8alpha-hydroxylabd-13-en-15-yl diphosphate [CPD:C21656]
Product
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Comment
Isolated from the plant Salvia miltiorrhiza (red sage).
History
EC 4.2.1.173 created 2017
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22946  ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase
Genes
SMIL130999236
Reference
1  [PMID:26077765]
  Authors
Cui G, Duan L, Jin B, Qian J, Xue Z, Shen G, Snyder JH, Song J, Chen S, Huang L, Peters RJ, Qi X
  Title
Functional Divergence of Diterpene Syntheses in the Medicinal Plant Salvia miltiorrhiza.
  Journal
Plant Physiol 169:1607-18 (2015)
DOI:10.1104/pp.15.00695
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.173
IUBMB Enzyme Nomenclature: 4.2.1.173
ExPASy - ENZYME nomenclature database: 4.2.1.173
BRENDA, the Enzyme Database: 4.2.1.173

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