KEGG   ENZYME: 4.2.1.177
Entry
EC 4.2.1.177                Enzyme                                 
Name
(2S)-3-sulfopropanediol dehydratase;
hpfG (gene name);
(S)-DHPS dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(2S)-2,3-dihydroxypropane-1-sulfonate hydro-lyase
Reaction(IUBMB)
(2S)-2,3-dihydroxypropane-1-sulfonate = 3-oxopropane-1-sulfonate + H2O [RN:R12762]
Reaction(KEGG)
R12762
Substrate
(2S)-2,3-dihydroxypropane-1-sulfonate [CPD:C22383]
Product
3-oxopropane-1-sulfonate [CPD:C22384];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacterium Klebsiella oxytoca, participates in (2S)-2,3-dihydroxypropane-1-sulfonate degradation. The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (AdoMet) and a [4Fe-4S] cluster.
History
EC 4.2.1.177 created 2021
Orthology
K25255  (2S)-3-sulfopropanediol dehydratase
Genes
KLW: DA718_17260
VSH: BSZ05_23405
PACE: A6070_10230
DWD: DSCW_25080(pflF)
ECAS: ECBG_00900
HAS: Halsa_0723
IPO: Ilyop_0053 Ilyop_0060
Reference
1  [PMID:32571930]
  Authors
Liu J, Wei Y, Lin L, Teng L, Yin J, Lu Q, Chen J, Zheng Y, Li Y, Xu R, Zhai W, Liu Y, Liu Y, Cao P, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate.
  Journal
Proc Natl Acad Sci U S A 117:15599-15608 (2020)
DOI:10.1073/pnas.2003434117
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.177
IUBMB Enzyme Nomenclature: 4.2.1.177
ExPASy - ENZYME nomenclature database: 4.2.1.177
BRENDA, the Enzyme Database: 4.2.1.177

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (8)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (4)   
   InterPro (4)   
All databases (19)   

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