KEGG   ENZYME: 4.2.1.178
Entry
EC 4.2.1.178                Enzyme                                 
Name
difructose-dianhydride-III synthase;
DFA-IIIase;
difructose anhydride III hydrolase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
inulobiose hydro-lyase (alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride-forming)
Reaction(IUBMB)
inulobiose = alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O [RN:R12927]
Reaction(KEGG)
R12927
Substrate
inulobiose [CPD:C01711]
Product
alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride [CPD:C04420];
H2O [CPD:C00001]
Comment
The enzyme participates in an inulin degradation pathway, in which it forms inulobiose from difructose anhydride III. A conformational change in the enzyme from the bacterium Pseudarthrobacter chlorophenolicus results in it also catalysing the activity of EC 4.2.2.18, inulin fructotransferase (DFA-III-forming).
History
EC 4.2.1.178 created 2021
Orthology
K25596  difructose-dianhydride-III synthase
Genes
KVAKvar_5014
KPKA593_11155
KVDKR75_08560
KOXKOX_07155
KOEA225_0068
KOYJ415_02590
KOMHR38_05695
KOKKONIH1_00335
KOCAB185_06645
KGRJJJ10_27210
KPASLUW96_07080
KLCK7H21_27435
KLMBWI76_00635
RORRORB6_18285
RONTE10_07105
RPLNB1209_26505
KLUK7B04_01090
LERGNG29_05760
KINAB182_13660
SRLSOD_c28250
SRYM621_15425
SERMCLM71_06785
SFJSAMEA4384070_2039
SRHZFO014_03060
RAQRahaq2_5077
ROXBV494_15295
RBONQNM34_08325
DDQDDI_2040
MHANK6958_15770
HPARAL518_09555
EAKEKH55_4419
STEGQA637_22130
ATFAch5_48470
RETRHE_PE00355
RELREMIM1_PD00373
REPIE4803_PD00527
REIIE4771_PE00542
RLTRleg2_5748
RLGRleg_4711
RLURLEG12_01740
RHLLPU83_pLPU83c0042
RHNAMJ98_PD00372
RPHAAMC79_PA00132
RHXAMK02_PE00373
RHKKim5_PD00500
REZAMJ99_PC00373
RIIFFM53_024865
RHIDFFM81_030170
RBQJ2J99_26115
RLNJ0663_28945
RBANJ2J98_25555
RRGJ3P73_25535
RSULN2599_25805
BIFN288_04325
BCABEFK13_09610
BACQDOE78_03600
GRCGI584_09785
MSEMGMB29_03050
PMWB2K_10350
PWNQNH46_17500
LHIJP39_12245
LDXLH506_03595
LMMMI1_04685
EAVEH197_20055
CBEILF65_04373
RUMCK1_34800
BHANCGC63_02550
BLARLC508_12690
BHVBLHYD_09270
LBWC3V36_09770
ARTArth_0051
ARRARUE_c06600
ARHAHiyo8_09220
ARZAUT26_18675
ARQBWQ92_22735
ARNCGK93_03645
ARXARZXY2_4154
ARTHC3B78_17440
AODQ8Z05_08270
AAUAAur_0696
PUEFV140_20445
PNVJMY29_03080 JMY29_03120
ACHAchl_2895
APNAsphe3_30430
PSULAU252_08925
POKSMD14_09400
NOQLN652_00405
KSLOG809_19905
ASLANCTC11923_01836
 » show all
Reference
1  [PMID:1225919]
  Authors
Tanaka T, Uchiyama T, Kobori H, Tanaka K.
  Title
Enzymic hydrolysis of di-D-fructofuranose 1, 2'; 2, 3' dianhydride with Arthrobacter ureafaciens.
  Journal
J Biochem 78:1201-6 (1975)
DOI:10.1093/oxfordjournals.jbchem.a131017
Reference
2
  Authors
Neubauer, A., Walter, M., and Buchholz, K.
  Title
Formation of inulobiose from difructoseanhydride III catalysed by a lysate from Arthrobacter ureafaciens ATCC 21124.
  Journal
Biocatalysis and Biotransformation 18:443-455 (2000)
Reference
3  [PMID:16233453]
  Authors
Saito K, Sumita Y, Nagasaka Y, Tomita F, Yokota A.
  Title
Molecular cloning of the gene encoding the di-D-Fructofuranose 1,2':2,3' dianhydride hydrolysis enzyme (DFA IIIase) from Arthrobacter sp. H65-7.
  Journal
J Biosci Bioeng 95:538-40 (2003)
DOI:10.1016/s1389-1723(03)80058-0
  Sequence
Reference
4  [PMID:26555784]
  Authors
Yu S, Wang X, Zhang T, Stressler T, Fischer L, Jiang B, Mu W.
  Title
Identification of a Novel Di-D-Fructofuranose 1,2':2,3' Dianhydride (DFA III) Hydrolysis Enzyme from Arthrobacter aurescens SK8.001.
  Journal
PLoS One 10:e0142640 (2015)
DOI:10.1371/journal.pone.0142640
Reference
5
  Authors
Yu, S., Shen, H., Cheng, Y., Zhu, Y., Li, X., and Mu, W.
  Title
Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue.
  Journal
ACS Catalysis 8:10683-10697 (2018)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.178
IUBMB Enzyme Nomenclature: 4.2.1.178
ExPASy - ENZYME nomenclature database: 4.2.1.178
BRENDA, the Enzyme Database: 4.2.1.178

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