KEGG   ENZYME: 4.2.1.182
Entry
EC 4.2.1.182                Enzyme                                 
Name
phosphomevalonate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
R-5-phosphomevalonate hydro-lyase
Reaction(IUBMB)
(R)-5-phosphomevalonate = trans-anhydromevalonate 5-phosphate + H2O [RN:R12894]
Reaction(KEGG)
R12894
Substrate
(R)-5-phosphomevalonate [CPD:C01107]
Product
trans-anhydromevalonate 5-phosphate [CPD:C22453];
H2O [CPD:C00001]
Comment
The enzyme catalyses a step in an archaeal prenyl diphosphate biosynthesis pathway. It belongs to the aconitase X family, and contains a [4Fe-4S] cluster.
History
EC 4.2.1.182 created 2023
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09128  phosphomecalonate degydratase small subunit
K25517  phosphomecalonate degydratase large subunit
Genes
MAER: DAI18_17280
PNW: SYK_15530
DEK: DSLASN_10080
AGAT: RWV98_01370 RWV98_05425 RWV98_05430
BHV: BLHYD_07890
CHYL: CE91St63_25950 CE91St63_25960
ETM: CE91St48_33550
SGRG: L0C25_12915
ACIR: OG979_31240
MHAW: RMN56_28590
LUB: TBR22_A12610
MJA: MJ_1313 MJ_1407
MFE: Mefer_0080 Mefer_1421
MVU: Metvu_1202 Metvu_1439
MFS: MFS40622_0336 MFS40622_0378
MIF: Metin_0203 Metin_0709
MJH: JH146_0315 JH146_0335
MESG: MLAUSG7_1120 MLAUSG7_1129
MESA: MLASG1_0646 MLASG1_0655
MIG: Metig_1406 Metig_1502
MMP: MMP0902 MMP1663
MMQ: MmarC5_0709 MmarC5_1745
MMX: MmarC6_1010 MmarC6_1754
MMZ: MmarC7_0149 MmarC7_0935
MMD: GYY_05225 GYY_09170
MMAK: MMKA1_09990 MMKA1_18950
MMAO: MMOS7_09770 MMOS7_17760
MMAD: MMJJ_00900 MMJJ_11690
MAE: Maeo_0452 Maeo_1036
MVN: Mevan_0019 Mevan_0963
MVO: Mvol_0933 Mvol_1301
MOK: Metok_0423 Metok_0993
METF: CFE53_03445 CFE53_03920
MTH: MTH_1421 MTH_1530
MMG: MTBMA_c00090 MTBMA_c01130
MWO: MWSIV6_0069 MWSIV6_1799
MTEE: MTTB_00060 MTTB_15270
METC: MTCT_1292 MTCT_1393
METE: tca_01372 tca_01478
METZ: METMT2_0007 METMT2_0081
METK: FVF72_03975 FVF72_04490
MTHM: FZP57_00285 FZP57_08815
METJ: FZP68_01415 FZP68_01915
MST: Msp_0008 Msp_0225
METB: AW729_06040 AW729_07300
MEIS: PXD04_03700 PXD04_04930
MRU: mru_0202 mru_2095
MSI: Msm_1155 Msm_1192
MEB: Abm4_0086 Abm4_0127
MMIL: sm9_0097 sm9_0159
MEYE: TL18_10020 TL18_10225
MOL: YLM1_1724 YLM1_1820
MARO: MarbSA_10890 MarbSA_11580
METV: K4897_05435 K4897_05640
MEL: Metbo_0003 Metbo_0105
MEW: MSWAN_0095 MSWAN_2414
METH: MBMB1_0075 MBMB1_2037
MFC: BRM9_0006 BRM9_0139
MFI: DSM1535_1324 DSM1535_1462
MCUB: MCBB_0100 MCBB_2333
MSUB: BK009_09450 BK009_09950
METN: BK008_05200 BK008_05790
METT: CIT01_05450 CIT01_06045
METO: CIT02_06640 CIT02_07305
MEME: HYG87_06310 HYG87_06935
MFEG: GCM10025860_07210 GCM10025860_08750
MFV: Mfer_0495 Mfer_0905
MKA: MK1486 MK1639
AFU: AF_0055 AF_2333
AFG: AFULGI_00000480 AFULGI_00026330
APO: Arcpr_0690 Arcpr_1395
AVE: Arcve_0619 Arcve_1712
AST: Asulf_00141 Asulf_00994
FPL: Ferp_0107 Ferp_0108
GAC: GACE_1778 GACE_1779
GAH: GAH_00857 GAH_00858
PFU: PF0390 PF0391
PFI: PFC_01030 PFC_01035
PHO: PH0353(PH0353) PH0354(PH0354)
PAB: PAB1061 PAB1062
PYN: PNA2_0962 PNA2_0963
PYA: PYCH_13830 PYCH_13840
PYS: Py04_0661 Py04_0662
PYC: TQ32_03560 TQ32_03565
TKO: TK1248 TK1249
TON: TON_0513 TON_0514
TGA: TGAM_1119(acnX) TGAM_1120(acnX)
TSI: TSIB_1943 TSIB_1944
TBA: TERMP_00892 TERMP_00893
THE: GQS_02585 GQS_02590
THA: TAM4_1938 TAM4_2182
THM: CL1_0165 CL1_0166
TLT: OCC_10319 OCC_10324
THS: TES1_0898 TES1_0899
TNU: BD01_0420 BD01_0421
TEU: TEU_08600 TEU_08605
TGY: X802_08765 X802_08770
THV: ADU37_CDS20780 ADU37_CDS20790
TCH: CHITON_1180 CHITON_1181
TPEP: A0127_08680 A0127_08685
TPIE: A7C91_08615 A7C91_08620
TGG: A3K92_05205 A3K92_05210
TCE: A3L02_02475 A3L02_02480
TBS: A3L01_03300 A3L01_03305
THH: CDI07_03235 CDI07_03240
TSL: A3L11_07275 A3L11_07280
TTD: A3L14_04985 A3L14_04990
TPRF: A3L09_07630 A3L09_07635
TRL: A3L10_03265 A3L10_03270
TPAF: A3L08_06355 A3L08_06360
THY: A3L12_05565 A3L12_05570
TIC: FH039_05850 FH039_05855
TCQ: TIRI35C_0894 TIRI35C_0895
THEM: FPV09_03495 FPV09_03500
THEI: K1720_02455 K1720_02460
PPAC: PAP_03695 PAP_03700
MBA: Mbar_A0717 Mbar_A0718
MBY: MSBRM_0327 MSBRM_0328
MBW: MSBRW_0283 MSBRW_0284
MBAR: MSBR2_2053 MSBR2_2054
MBAK: MSBR3_2122 MSBR3_2123
MAC: MA_0244 MA_0245
MMA: MM_1524 MM_1525
MMAZ: MmTuc01_1583 MmTuc01_1584
MMJ: MSMAS_3142 MSMAS_3143
MMAC: MSMAC_3162 MSMAC_3163
MVC: MSVAZ_0316 MSVAZ_0317
MEK: MSKOL_0300 MSKOL_0301
MLS: MSLAZ_0092 MSLAZ_0093
METM: MSMTP_3040 MSMTP_3041
MEF: MSWH1_0171 MSWH1_0172
MEQ: MSWHS_0170 MSWHS_0171
MSJ: MSSAC_0230 MSSAC_0231
MSZ: MSSIH_0199 MSSIH_0200
MSW: MSSIT_0203 MSSIT_0204
MTHR: MSTHT_2040 MSTHT_2041
MTHE: MSTHC_1245 MSTHC_1246
MHOR: MSHOH_3879 MSHOH_3880
MFZ: AOB57_009515 AOB57_009520
MBU: Mbur_1471 Mbur_1472
MMET: MCMEM_1971 MCMEM_1972
MELO: J7W08_08745 J7W08_08750
MMH: Mmah_1771 Mmah_1772
MHAZ: BHR79_04820 BHR79_04825
MPOT: BKM01_00945 BKM01_00950
MEV: Metev_2054 Metev_2055
MZH: Mzhil_1539 Mzhil_1540
MPY: Mpsy_2251 Mpsy_2252
MZI: HWN40_10875 HWN40_10880
MMAV: RE476_12220 RE476_12225
MSEB: RE474_09110 RE474_09115
MHZ: Metho_2163 Metho_2164
MEHF: MmiHf6_15590 MmiHf6_15600
MEES: MmiEs2_00950 MmiEs2_00960
MTP: Mthe_0207 Mthe_0208
MCJ: MCON_2874 MCON_2875
MHI: Mhar_1471 Mhar_1472
MHU: Mhun_1041 Mhun_2437
MRTJ: KHC33_11740 KHC33_16800
MLA: Mlab_0056 Mlab_0800
MEM: Memar_1309 Memar_2138
MBG: BN140_1346 BN140_2051
MEMA: MMAB1_1715 MMAB1_2659
MCHK: MchiMG62_14940 MchiMG62_24470
MSUM: OH143_00780 OH143_04975
MRC: R6Y96_01585 R6Y96_07365
MPI: Mpet_1883 Mpet_2083
MEND: L6E24_01025 L6E24_10800
MEFW: F1737_02315 F1737_03010
MAQE: RJ40_06745 RJ40_12530
MFK: E2N92_00350 E2N92_06910
MOU: OU421_09620 OU421_11465
MESB: L1S32_00815 L1S32_03355
MANQ: L1994_03865 L1994_07210
MBN: Mboo_0123 Mboo_1457
MFO: Metfor_0251 Metfor_1534
MPL: Mpal_0506 Mpal_0511
MPD: MCP_2308 MCP_2309
MEZ: Mtc_1230 Mtc_1231
RCI: LRC241 LRC243
HALH: HTSR_1040 HTSR_1041
HHSR: HSR6_1073 HSR6_1074
HSU: HLASF_0830 HLASF_0831
HSF: HLASA_0827 HLASA_0828
HAHS: HSRCO_1216 HSRCO_1217
HUT: Huta_0615 Huta_0616
HTI: HTIA_0363 HTIA_0364
HALA: Hrd1104_02525 Hrd1104_02530
HASV: SVXHr_1978 SVXHr_1979
HABN: HBNXHr_1965 HBNXHr_1966
HDS: HSR122_0650 HSR122_0651
HARC: HARCEL1_02635 HARCEL1_02640
HDF: AArcSl_1771 AArcSl_1772
HAAA: AArcCO_0145 AArcCO_0146
MELU: MTLP_11110
MEAM: MU439_04160 MU439_04165
MEAE: QEN48_05810 QEN48_05815
TAR: TALC_00511 TALC_00512
MAX: MMALV_04600 MMALV_04610
MER: MMINT_07310 MMINT_07320
MEAR: Mpt1_c03820 Mpt1_c03830(nudI)
MEUZ: KRP56_05840 KRP56_05845
MARC: AR505_0453 AR505_0454
ABI: Aboo_0848 Aboo_0849
ACF: AciM339_0156 AciM339_0157
APE: APE_2087.1 APE_2089
ACJ: ACAM_1307 ACAM_1308
SMR: Smar_0622 Smar_0623
SHC: Shell_0172 Shell_0173
IHO: Igni_0694 Igni_0695
IIS: EYM_07505 EYM_07510
IPC: IPA_09450 IPA_09455
DKA: DKAM_0142 DKAM_0143
DFD: Desfe_0217 Desfe_0218
DMU: Desmu_0693 Desmu_0694
TAG: Tagg_1154 Tagg_1155
IAG: Igag_1937 Igag_1938
THG: TCELL_0122 TCELL_0123
HBU: Hbut_1633 Hbut_1634
PFM: Pyrfu_0193 Pyrfu_0194
PDL: Pyrde_0502 Pyrde_0503
PABI: PABY_02540 PABY_02550
PARE: PYJP_14510 PYJP_14520
PAI: PAE2233 PAE2234
PIS: Pisl_0854 Pisl_0855
PCL: Pcal_0949 Pcal_0950
PAS: Pars_1919 Pars_1920
PYR: P186_0458 P186_0459
POG: Pogu_0207 Pogu_0208
TNE: Tneu_1398 Tneu_1399
PYW: PYWP30_01479 PYWP30_01480
CMA: Cmaq_0991 Cmaq_1865
TTN: TTX_1589 TTX_1590
TUZ: TUZN_1948 TUZN_1949
VDI: Vdis_1832 Vdis_2182
VMO: VMUT_0272 VMUT_0577
VSO: Vsou_22030
TPE: Tpen_0796 Tpen_0797
THB: N186_05490 N186_05495
TCB: TCARB_0165 TCARB_0166
THF: MA03_05620 MA03_05625
THEL: IG193_03585 IG193_03590
ASC: ASAC_0163 ASAC_0164
ACIA: SE86_01575 SE86_01580
CLG: Calag_0818 Calag_0819
FFO: FFONT_1070 FFONT_1071
NMR: Nmar_0053 Nmar_0054
NIR: NSED_09895 NSED_09900
NKR: NKOR_00040 NKOR_00045
NID: NPIRD3C_0317 NPIRD3C_0318
NIN: NADRNF5_0013 NADRNF5_0014
NIW: Nisw_04720 Nisw_04725
NCL: C5F47_00265 C5F47_00270
NOX: C5F49_00260 C5F49_00265
NUE: C5F50_00270
NIP: NsoK4_08930 NsoK4_08935
NZT: NZOSNM25_002057 NZOSNM25_002058
NCT: NMSP_0055 NMSP_0056
NIC: DSQ20_00305 DSQ20_00310
NGA: Ngar_c08140 Ngar_c08150
NVN: NVIE_012770 NVIE_012780
NEV: NTE_02684 NTE_02685
TAA: NMY3_03541 NMY3_03542
NFN: NFRAN_0895 NFRAN_0896
NCV: NCAV_0093 NCAV_0094
CSY: CENSYa_1907 CENSYa_1908
NBV: T478_0049 T478_0051
TAH: SU86_006495 SU86_006500
NIU: DSQ19_10210 DSQ19_10215
NCK: QVH35_02940 QVH35_02950
NDV: NDEV_0071 NDEV_0072
CCAI: NAS2_0339 NAS2_1614
KCR: Kcr_1257
BARC: AOA65_2273 AOA65_2274
BARB: AOA66_0499
FLT: Sv326_0059 Sv326_0060
LOKI: Lokiarch_22740 Lokiarch_22750
 » show all
Reference
1  [PMID:31924615]
  Authors
Yoshida R, Yoshimura T, Hemmi H.
  Title
Reconstruction of the "Archaeal" Mevalonate Pathway from the Methanogenic Archaeon Methanosarcina mazei in Escherichia coli Cells.
  Journal
Appl Environ Microbiol 86:AEM.02889-19 (2020)
DOI:10.1128/AEM.02889-19
  Sequence
[mma:MM_1525 MM_1524]
Reference
2  [PMID:36992929]
  Authors
Komeyama M, Kanno K, Mino H, Yasuno Y, Shinada T, Ito T, Hemmi H.
  Title
A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway.
  Journal
Front Microbiol 14:1150353 (2023)
DOI:10.3389/fmicb.2023.1150353
  Sequence
[ape:APE_2087.1 APE_2089]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.182
IUBMB Enzyme Nomenclature: 4.2.1.182
ExPASy - ENZYME nomenclature database: 4.2.1.182
BRENDA, the Enzyme Database: 4.2.1.182

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3459)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (541)   
   KEGG MGENES (2916)   
All databases (3471)   

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