KEGG ENZYME: 4.2.1.54

ENZYME: 4.2.1.54

Entry

EC 4.2.1.54                 Enzyme

Name

lactoyl-CoA dehydratase;
lactoyl coenzyme A dehydratase;
lactyl-coenzyme A dehydrase;
lactyl CoA dehydratase;
acrylyl coenzyme A hydratase;
lactoyl-CoA hydro-lyase

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

(R)-lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)

Reaction(IUBMB)

(R)-lactoyl-CoA = acryloyl-CoA + H2O [RN:R02963]

Reaction(KEGG)

R02963

Substrate

(R)-lactoyl-CoA

Product

acryloyl-CoA [CPD:C00894];
H2O [CPD:C00001]

Comment

A bacterial enzyme that is involved in propanoate fermentation (also known as the acrylate pathway).

History

EC 4.2.1.54 created 1972, modified 2012

Pathway

ec00640

Propanoate metabolism

ec00643

Styrene degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K20626

lactoyl-CoA dehydratase subunit alpha

K20627

lactoyl-CoA dehydratase subunit beta

Genes

CNO:	NT01CX_2368(hgdB) NT01CX_2369(hgdA)

CBN:	CbC4_1682 CbC4_1683

RPAY:

P0092_20145

DOR:	Desor_3092 Desor_3093

DMI:	Desmer_1800 Desmer_1801

CCT:	CC1_11640 CC1_11650

CPRO:

CPRO_08380(fldB) CPRO_08390(fldC)

ANV:	RBQ60_10360 RBQ60_10365

MED:	MELS_0745 MELS_0746

MEG:	DKB62_04095 DKB62_04100

MMAX:

LCQ47_06140 LCQ47_06145

FNF:	BSQ88_08500 BSQ88_08505

» show all

Reference

1 [PMID:14292829]

Authors

BALDWIN RL, WOOD WA, EMERY RS.

Title

LACTATE METABOLISM BY PEPTOSTREPTOCOCCUS ELSDENII: EVIDENCE FOR LACTYL COENZYME A DEHYDRASE.

Journal

Biochim Biophys Acta 97:202-13 (1965)
DOI:10.1016/0304-4165(65)90084-X

Reference

2 [PMID:6586495]

Authors

Schweiger G, Buckel W

Title

On the dehydration of (R)-lactate in the fermentation of alanine to propionate by Clostridium propionicum.

Journal

FEBS Lett 171:79-84 (1984)
DOI:10.1016/0014-5793(84)80463-9

Reference

3 [PMID:4055736]

Authors

Kuchta RD, Abeles RH

Title

Lactate reduction in Clostridium propionicum. Purification and properties of lactyl-CoA dehydratase.

Journal

J Biol Chem 260:13181-9 (1985)

Sequence

[ag:AEM62994 AEM62993]

Reference

4 [PMID:3026450]

Authors

Kuchta RD, Hanson GR, Holmquist B, Abeles RH

Title

Fe-S centers in lactyl-CoA dehydratase.

Journal

Biochemistry 25:7301-7 (1986)
DOI:10.1021/bi00371a009

Reference

5 [PMID:1597194]

Authors

Hofmeister AE, Buckel W

Title

(R)-lactyl-CoA dehydratase from Clostridium propionicum. Stereochemistry of the dehydration of (R)-2-hydroxybutyryl-CoA to crotonyl-CoA.

Journal

Eur J Biochem 206:547-52 (1992)
DOI:10.1111/j.1432-1033.1992.tb16958.x

Sequence

[ag:AEM62994 AEM62993]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.54

IUBMB Enzyme Nomenclature:

4.2.1.54

ExPASy - ENZYME nomenclature database:

4.2.1.54

UM-BBD (Biocatalysis/Biodegradation Database):

4.2.1.54

BRENDA, the Enzyme Database:

4.2.1.54

CAS:

9031-12-3

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