KEGG ENZYME: 4.2.1.57

ENZYME: 4.2.1.57

Entry

EC 4.2.1.57                 Enzyme

Name

isohexenylglutaconyl-CoA hydratase;
3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase;
isohexenylglutaconyl coenzyme A hydratase;
beta-isohexenylglutaconyl-CoA-hydratase;
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]

Reaction(IUBMB)

3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O [RN:R03493]

Reaction(KEGG)

R03493

Substrate

3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA [CPD:C04675]

Product

3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA [CPD:C01291];
H2O [CPD:C00001]

Comment

Also acts on dimethylacryloyl-CoA and farnesoyl-CoA.

History

EC 4.2.1.57 created 1972

Pathway

ec00907

Pinene, camphor and geraniol degradation

ec01120

Microbial metabolism in diverse environments

Orthology

K13779

isohexenylglutaconyl-CoA hydratase

Genes

RGL:	CS053_05365

PAE:	PA2890(atuE)

PAEV:

N297_2993

PAEI:

N296_2993

PAU:	PA14_26690

PAP:	PSPA7_2264

PAG:	PLES_21741(atuE)

PAF:	PAM18_2073(atuE)

PNC:	NCGM2_4001

PAEB:

NCGM1900_3421

PDK:	PADK2_09920

PSG:	G655_10355

PRP:	M062_15480

PAEP:

PA1S_10960

PAER:

PA1R_gp0722

PAEM:

U769_10500

PAEL:

T223_10970

PAES:

SCV20265_2216

PAEU:

BN889_03228(atuE)

PAEG:

AI22_22910

PAEC:

M802_2990

PAEO:

M801_2858

PMY:

Pmen_2693

PMK:

MDS_2025

PRE:	PCA10_37640

PPSE:

BN5_2437

PFUW:

KF707C_19280

PALC:

A0T30_09825

PCQ:	PcP3B5_19980(echA8_1)

PMUI:

G4G71_19930

PNT:	G5B91_21660

PPAA:

B7D75_10680

PFL:	PFL_4198(atuE)

PPRC:

PFLCHA0_c42610(echA5)

PPRO:

PPC_4295(atuE)

PFN:	HZ99_27645

PFO:	Pfl01_3949

PFS:

PFLU_4396

PFC:	PflA506_3700(atuE)

PFB:

VO64_5140

PMAN:

OU5_1499

PTV:	AA957_22840

PVR:	PverR02_22375

PAZO:

AYR47_28665

PRX:	HRH33_19065

PKR:	AYO71_21560

PMUD:

NCTC8068_01873(echA8_2)

PTOL:

I7845_20330

PFW:	PF1751_v1c38910(atuE)

PFF:	PFLUOLIPICF716745

PFX:	A7318_18705

PPUU:

PputUW4_01474

PDR:	H681_15885

PSK:	U771_22890

PKC:

PKB_3705

PCH:	EY04_21280

PCZ:	PCL1606_19670

PCHP:

C4K32_4370

PSOS:

POS17_4286(atuE)

PFK:	PFAS1_02935

PANR:

A7J50_4074

PSET:

THL1_3722

PSIL:

PMA3_07215

PYM:	AK972_1689

PKE:	DLD99_19840

PALL:

UYA_10250

PUM:	HGP31_23190

POJ:	PtoMrB4_17780(atuE)

PGY:	AWU82_00340

PLAL:

FXN65_18465

PSEJ:

HNQ25_14635

PKH:	JLK41_10345(atuE)

PTY:	JWV26_20535

PMAO:

PMYSY11_2044

PATA:

JWU58_09110

PZE:	HU754_020990

PMOE:

HV782_020190

PCAM:

HNE05_10000

PSEP:

C4K39_6116

PPII:

QL104_21735

PVW:	HU752_023690

PTRT:

HU722_0020660

PSAM:

HU731_007040

PTZ:	HU718_021185

PSHH:

HU773_010440

PHV:	HU739_020395

PASG:

KSS96_20310

PAZE:

KSS91_08300

PWZ:	J7655_12405(atuE)

PTW:	TUM18999_18970(atuE)

PIE:	HU724_019815

PGF:	J0G10_21215

PCAV:

D3880_13540

PHF:	NLY38_09540(atuE)

PIZ:	LAB08_R42970

PPEG:

KUA23_21415

PSII:

NF676_18780

PFIT:

KJY40_20405

PNB:	NK667_04920

PSOA:

PSm6_39710(atuE)

PKJ:	Q1W70_18460

PHYG:

JTY93_09485

PHOM:

KJF94_17625

PCHE:

QYM18_17680(atuE)

PCUC:

PSH97_19625

PTRL:

OU419_19265(atuE)

PPAE:

LDL65_02155

HPEG:

EAO82_15110

PDEN:

F1C79_13295

MAQ:

Maqu_2806

MHC:

MARHY2693

MAD:

HP15_2541

MSX:	AU14_06535

MARI:

ACP86_03035

MLQ:	ASQ50_05315

MSQ:	BKP64_01775

MARA:

D0851_06245

MARJ:

MARI_02970(echA8_1)

MALL:

PBN92_14035

MSHE:

MAALD49_27830(ech2)

MANP:

EHN06_14595

MSAN:

LPB19_15780

KAK:	Kalk_03350

ACB:

A1S_3006

ABM:

ABSDF2869

ABY:

ABAYE0482

ABC:	ACICU_03205

ABN:

AB57_3457

ABB:	ABBFA_00511(echA8_1)

ABX:

ABK1_3257

ABZ:	ABZJ_03389

ABR:	ABTJ_00493

ABD:	ABTW07_3421

ABH:

M3Q_3438

ABAD:

ABD1_28950

ABJ:	BJAB07104_03294

ABAB:

BJAB0715_03357

ABAJ:

BJAB0868_03250

ABAZ:

P795_2375

ABK:	LX00_16130

ABAU:

IX87_11725

ABAA:

IX88_17970

ABW:	BL01_15700

ACC:	BDGL_002470(ech2)

ANO:	RR32_02585

ALC:	OTEC02_02500

ACAL:

BUM88_16985

ASEI:

I8T81_02655

ACD:	AOLE_02445

ACW:	A0J50_02390

ACV:	AMD27_02945

AHL:	AHTJS_02680

AJN:	BVL33_14910

ADV:	DJ533_05380

AWU:	BEN71_15680

AGU:	AS4_37350(liuC)

ADS:	FPL17_17120

ABER:

BSR55_18365

ALJ:	G8D99_12455

ASHA:

G8E00_03480

AGYL:

FPL18_09805

AVZ:	HWI77_02525

APRL:

PY247_02450

ACOI:

NQU59_06185

AVIV:

LF296_15875

ACIE:

KIP84_02595

MBAH:

HYN46_03590

THAT:

H3N35_16300

TACT:

SG35_017195

TVD:	SG34_012005

AMH:	I633_00605

AMB:	AMBAS45_14995

GAG:	Glaag_3942

PAT:

Patl_0318

HMI:	soil367_12300

ALKM:

NKI27_15115

ASEM:

NNL22_11445

ALII:

QR722_12050

SAGA:

M5M_01895

SNAN:

I6N98_02115

OSG:	BST96_16505

MICC:

AUP74_02724(caiD_2)

MII:	BTJ40_09630

MICT:

FIU95_11175(caiD)

MICZ:

GL2_32310(atuE)

MVB:	MJO52_09445

KIM:	G3T16_17330

AFUS:

EYZ66_13125

PAQM:

E0F26_06415

CYQ:

Q91_1220

CZA:	CYCME_1208

CYY:	CPC19_06505

HCH:

HCH_05751

HAHE:

ENC22_05160

HAHH:

O5O45_31390

ABO:	ABO_0987(ech2)

ALN:	AS19_10500

ALCA:

ASALC70_04031(paaF_1)

ADI:	B5T_01798(ech2)

AXE:

P40_08545

APAC:

S7S_10300

TWAN:

HUF19_01590

OAI:	OLEAN_C05750(ech)

BMAR:

HF888_06875

BACZ:

KFF03_16430

OME:	OLMES_1767

EMP:	EZMO1_3984(atuE)

SOK:	D0B54_13390 D0B54_21520 D0B54_21680

FCE:	JN531_011725

GPB:	HDN1F_10700

RPJ:	N234_26495

REH:	H16_A2138(h16_A2138)

CNC:	CNE_1c27020

CUH:	BJN34_26635

REU:	Reut_B4461

RME:

Rmet_1723

CBW:	RR42_s2503

CCUP:

BKK81_27005

CUP:	BKK80_29315

CUU:	BKK79_35265

COX:	E0W60_00885

CUK:	KB879_25960

BPS:

BPSS2033

BPM:	BURPS1710b_A1151

BPL:	BURPS1106A_A2776

BPD:	BURPS668_A2931

BPSE:

BDL_5456

BPSM:

BBQ_4088

BPSU:

BBN_5508

BPSD:

BBX_4623

BPZ:	BP1026B_II2188

BPQ:	BPC006_II2741

BPK:

BBK_4784

BPSH:

DR55_5688

BPSA:

BBU_3965

BPSO:

X996_5493

BUT:

X994_5050

BTE:	BTH_II0287

BTQ:

BTQ_3582

BTJ:

BTJ_4618

BTZ:

BTL_5405

BTD:

BTI_4953

BTV:

BTHA_4797

BTHE:

BTN_5076

BTHM:

BTRA_5344

BTHA:

DR62_5205

BTHL:

BG87_5412

BOK:

DM82_6352

BOC:

BG90_4322

BUU:	WS70_27685

BSAV:

WS86_29380

BHG:	I6G56_28270

BUD:	AQ610_30715

BUL:

BW21_4481

PMEG:

FNZ07_28820

AXY:	AXYL_05147 AXYL_05905 AXYL_06695

APES:

FOC84_18895

AKA:	TKWG_13775

RFR:

Rfer_2816

RSB:	RS694_04405

RHG:	EXZ61_04955

RHOA:

HZ993_09220

ACK:	C380_03330

ACRA:

BSY15_2085

ARAD:

KI609_03520

VEI:	Veis_2207 Veis_4192

CTT:	CtCNB1_1720

CTES:

O987_10850

CODO:

LAD35_12085

CRJ:	QMY55_09425

ADN:	Alide_0006 Alide_0191

ADK:	Alide2_0011 Alide2_0180

LIH:	L63ED372_00597(paaF_2)

HYR:	BSY239_341

HYB:

Q5W_16945

HYL:	LPB072_13945

HPSE:

HPF_03620(paaF2)

HTN:	KI616_23290

HCZ:	G9Q37_12945

DIH:	G7047_04265

SIMP:

C6571_17635

MELM:

C7H73_12860

RGE:

RGE_32890

RBN:	RBXJA2T_12974

PKT:	AT984_14395

SHD:	SUTH_02875

NIY:	FQ775_15165

PMOB:

HG718_07165

PECT:

BN1012_Phect2900

RVA:

Rvan_3071

RLAC:

QMO75_11350

RBM:	TEF_02215 TEF_19345

PSF:

PSE_4602

HDH:	G5B40_00900

GAK:

X907_0621

SECH:

B18_27410

SPHG:

AZE99_15810

SFLA:

SPHFLASMR4Y_02318(caiD)

SPHY:

CHN51_05355

PARJ:

J4G78_10640

PHAO:

HF685_10675

RFL:	Rmf_20530(atuE)

SRF:	LHU95_03865

RCE:

RC1_3532

TMO:

TMO_b0367

HFL:	PUV54_00655

SNEA:

NBZ79_16340

KOZ:	KFF44_13290

GSO:	PH603_16435

NANN:

O0S08_37805

TSD:	MTP03_45910(atuE)

PMET:

G4Y79_18165

SCOR:

J3U87_30230

» show all

Reference

1 [PMID:14339651]

Authors

SEUBERT W, FASS E.

Title

[STUDIES ON THE BACTERIAL DEGRADATION OF ISOPRENOIDS. IV. THE PURIFICATION AND PROPERTIES OF BETA-ISOHEXENYLGLUTACONYL-COA-HYDRATASE AND BETA-HYDROXY-BETA-ISOHEXENYLGLUTARYL-COA-LYASE.]

Journal

Biochem Z 341:23-34 (1964)

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.57

IUBMB Enzyme Nomenclature:

4.2.1.57

ExPASy - ENZYME nomenclature database:

4.2.1.57

UM-BBD (Biocatalysis/Biodegradation Database):

4.2.1.57

BRENDA, the Enzyme Database:

4.2.1.57

CAS:	37290-84-9

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