KEGG   ENZYME: 4.2.2.28
Entry
EC 4.2.2.28                 Enzyme                                 
Name
alpha-L-rhamnosyl-(1->4)-D-glucuronate lyase;
L-rhamnose-alpha-1,4-D-glucuronate lyase;
FoRham (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
Sysname
alpha-L-rhamnosyl-(1->4)-D-glucuronate lyase
Reaction(IUBMB)
alpha-L-rhamnosyl-(1->4)-D-glucuronate = L-rhamnopyranose + 4-deoxy-L-threo-hex-4-enopyranuronate [RN:R13297]
Reaction(KEGG)
R13297
Substrate
alpha-L-rhamnosyl-(1->4)-D-glucuronate [CPD:C22899]
Product
L-rhamnopyranose [CPD:C00507];
4-deoxy-L-threo-hex-4-enopyranuronate [CPD:C22712]
Comment
The enzyme, characterized from the phytopathogenic fungus Fusarium oxysporum, removes the rhamnosyl residue from alpha-L-rhamnosyl-(1->4)-D-glucuronate or (with lower activity) from oligosaccharides that contain this motif at the non-reducing end, leaving an unsaturated glucuronate residue. Among its natural substrates is the type II arabinogalactan component of gum arabic.
History
EC 4.2.2.28 created 2022, modified 2024
Orthology
K26349  alpha-L-rhamnosyl-(1->4)-beta-D-glucuronate lyase
Genes
FGR: FGSG_14002
FPU: FPSE_02402
FPOA: FPOAC1_007419
FVN: FVRRES_10681
FOX: FOXG_13355
NHE: NECHADRAFT_43140
FFC: NCS54_00822900
FKR: NCS57_00866100
FMU: J7337_007515
VAL: VDBG_10220
SAPO: SAPIO_CDS0694
PNO: SNOG_11050
PTE: PTT_12615
BZE: COCCADRAFT_92115
BSC: COCSADRAFT_351760
BOR: COCMIDRAFT_91267
AALT: CC77DRAFT_1029828
ARAB: EKO05_0010200
 » show all
Reference
1  [PMID:34303708]
  Authors
Kondo T, Kichijo M, Maruta A, Nakaya M, Takenaka S, Arakawa T, Fushinobu S, Sakamoto T.
  Title
Structural and functional analysis of gum arabic l-rhamnose-alpha-1,4-d-glucuronate lyase establishes a novel polysaccharide lyase family.
  Journal
J Biol Chem 297:101001 (2021)
DOI:10.1016/j.jbc.2021.101001
  Sequence
[fox:FOXG_13355]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.2.28
IUBMB Enzyme Nomenclature: 4.2.2.28
ExPASy - ENZYME nomenclature database: 4.2.2.28
BRENDA, the Enzyme Database: 4.2.2.28

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Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (18)   
Protein sequence (1)   
   PDBSTR (1)   
3D Structure (1)   
   PDB (1)   
All databases (25)   

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