KEGG ENZYME: 4.2.2.7

ENZYME: 4.2.2.7

Entry

EC 4.2.2.7                  Enzyme

Name

heparin lyase;
heparin eliminase;
heparinase

Class

Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides

Sysname

heparin lyase

Reaction(IUBMB)

Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends

History

EC 4.2.2.7 created 1972

Orthology

K19050

heparin lyase

K19051

heparin/heparan-sulfate lyase

Genes

ENW:	MJO57_09750

RUG:	QC826_22770

PKP:	SK3146_03003(hepB_1) SK3146_03009(hepB_2)

JET:	L3J17_02230

BTH:

BT_4675

BHL:	Bache_1608

BXY:

BXY_37770

BEG:	INE88_00172(hepB_1) INE88_00676 INE88_01239 INE88_01975(hepB_2)

BSTE:

K6V31_04695 K6V31_09835 K6V31_14055

BFE:	K6V30_11805

BNO:	K8P02_03590

BFC:	BacF7301_13715

BFIN:

BFINE_49650

PGOL:

K6V26_28040

COPR:

Cop2CBH44_22930 Cop2CBH44_22940 Cop2CBH44_27580

ASH:

AL1_01250

ASEN:

NQ519_12970

COY:	HF329_21215

NKO:	Niako_3778

ATEE:

K9M52_03115

PHE:	Phep_0472 Phep_2408

PSN:	Pedsa_0684

SPDR:

G6053_20175

STHA:

NCTC11429_03410

SSPI:

I6J01_21600

SMUI:

I6J00_00060

SSIY:

JVX97_22245

SENF:

GJR95_37505

ADD:	HUW48_04730

ASWU:

HUW51_12575

TPEL:

P0M28_18290 P0M28_23265

COC:

Coch_0606

» show all

Reference

1 [PMID:5484472]

Authors

Hovingh P, Linker A.

Title

The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria.

Journal

J Biol Chem 245:6170-5 (1970)

Other DBs

ExplorEnz - The Enzyme Database:

4.2.2.7

IUBMB Enzyme Nomenclature:

4.2.2.7

ExPASy - ENZYME nomenclature database:

4.2.2.7

BRENDA, the Enzyme Database:

4.2.2.7

CAS:

9025-39-2

DBGET integrated database retrieval system