KEGG   ENZYME: 4.2.2.8
Entry
EC 4.2.2.8                  Enzyme                                 
Name
heparin-sulfate lyase;
heparin-sulfate eliminase;
heparitin-sulfate lyase;
heparitinase I;
heparitinase II
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
Sysname
heparin-sulfate lyase
Reaction(IUBMB)
Elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.
Comment
Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.
History
EC 4.2.2.8 created 1972
Orthology
K19051  heparin/heparan-sulfate lyase
K19052  heparan-sulfate lyase
Genes
RUGQC826_22770
VEGSAMN05444156_2604
JETL3J17_02230
TAERGT409_07625
LPROPQO03_05670 PQO03_05680
BTHBT_4657 BT_4662
BTHOBtheta7330_03330(hepC_1) Btheta7330_03335(hepC_2)
BHLBache_1616
BXYBXY_37640 BXY_37690
BOABovatus_04863(hepC_2) Bovatus_04868(hepC_3)
BCELBcellWH2_01704(hepC)
BCAEA4V03_04720
BHFC3V43_00350
BISDXK01_000620
BEGINE88_00172(hepB_1) INE88_01080(hepC_1) INE88_01245(hepC_2) INE88_01975(hepB_2)
BSTEK6V31_02525 K6V31_04695 K6V31_09835 K6V31_14020 K6V31_14045
BFEK6V30_11670 K6V30_11705
BNOK8P02_03515
BFCBacF7301_13570 BacF7301_13595 BacF7301_13600
BFINBFINE_16790 BFINE_49980 BFINE_50170
PGOLK6V26_28040
COPRCop2CBH44_22930 Cop2CBH44_22940 Cop2CBH44_27650
ASHAL1_01210 AL1_01260
ASENNQ519_12975 NQ519_12980
MCOSGM418_02670
COYHF329_08420 HF329_21215
NKONiako_3778
NSONIASO_15680
NIAA8C56_05370
ATEEK9M52_03115
PHEPhep_2408 Phep_3797
PROEH9L23_14665
PSNPedsa_0684 Pedsa_1814 Pedsa_1818
SPDRG6053_20175
STHANCTC11429_03410
SSPII6J01_21600
SMUII6J00_00060
SSIYJVX97_22245
SBXCA265_11340
ADDHUW48_04730
ASWUHUW51_12575
TPELP0M28_18290 P0M28_23265
FBIL0669_15815
FCSTRV642_4548(hepC)
FPLUNLG42_15400 NLG42_15405
COCCoch_0606
 » show all
Reference
1  [PMID:5484472]
  Authors
Hovingh P, Linker A.
  Title
The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria.
  Journal
J Biol Chem 245:6170-5 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.2.8
IUBMB Enzyme Nomenclature: 4.2.2.8
ExPASy - ENZYME nomenclature database: 4.2.2.8
BRENDA, the Enzyme Database: 4.2.2.8
CAS: 37290-86-1

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