KEGG   ENZYME: 4.2.3.113
Entry
EC 4.2.3.113                Enzyme                                 
Name
terpinolene synthase;
ag9;
PmeTPS2;
LaLIMS_RR
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranyl-diphosphate diphosphate-lyase (cyclizing, terpinolene-forming)
Reaction(IUBMB)
geranyl diphosphate = terpinolene + diphosphate [RN:R02010]
Reaction(KEGG)
R02010
Substrate
geranyl diphosphate [CPD:C00341]
Product
terpinolene [CPD:C06075];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. Mn2+ is less effective and product ratio changes. Forms traces of other monoterpenoids.
History
EC 4.2.3.113 created 2012
Orthology
K21930  terpinolene synthase
Reference
1  [PMID:2768265]
  Authors
Croteau R, Satterwhite DM
  Title
Biosynthesis of monoterpenes. Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-)-pinene cyclases from sage.
  Journal
J Biol Chem 264:15309-15 (1989)
Reference
2  [PMID:10441373]
  Authors
Bohlmann J, Phillips M, Ramachandiran V, Katoh S, Croteau R
  Title
cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis).
  Journal
Arch Biochem Biophys 368:232-43 (1999)
DOI:10.1006/abbi.1999.1332
  Sequence
[ag:AAF61454]
Reference
3  [PMID:12602896]
  Authors
Faldt J, Martin D, Miller B, Rawat S, Bohlmann J
  Title
Traumatic resin defense in Norway spruce (Picea abies): methyl jasmonate-induced terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthase.
  Journal
Plant Mol Biol 51:119-33 (2003)
DOI:10.1023/A:1020714403780
Reference
4  [PMID:15921711]
  Authors
Huber DP, Philippe RN, Godard KA, Sturrock RN, Bohlmann J
  Title
Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesii.
  Journal
Phytochemistry 66:1427-39 (2005)
DOI:10.1016/j.phytochem.2005.04.030
Reference
5  [PMID:17662687]
  Authors
Landmann C, Fink B, Festner M, Dregus M, Engel KH, Schwab W
  Title
Cloning and functional characterization of three terpene synthases from lavender (Lavandula angustifolia).
  Journal
Arch Biochem Biophys 465:417-29 (2007)
DOI:10.1016/j.abb.2007.06.011
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.113
IUBMB Enzyme Nomenclature: 4.2.3.113
ExPASy - ENZYME nomenclature database: 4.2.3.113
BRENDA, the Enzyme Database: 4.2.3.113

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (45)   
   UniProt (20)   
   SWISS-PROT (18)   
   RefSeq(pep) (7)   
DNA sequence (7)   
   RefSeq(nuc) (7)   
Protein domain (8)   
   InterPro (8)   
All databases (67)   

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