KEGG   ENZYME: 4.2.3.115
Entry
EC 4.2.3.115                Enzyme                                 
Name
alpha-terpinene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranyl-diphosphate diphosphate-lyase (cyclizing, alpha-terpinene-forming)
Reaction(IUBMB)
geranyl diphosphate = alpha-terpinene + diphosphate [RN:R09970]
Reaction(KEGG)
R09970
Substrate
geranyl diphosphate [CPD:C00341]
Product
alpha-terpinene [CPD:C09898];
diphosphate [CPD:C00013]
Comment
The enzyme has been characterized from Dysphania ambrosioides (American wormseed). Requires Mg2+. Mn2+ is less effective. The enzyme will also use (3R)-linalyl diphosphate. The reaction involves a 1,2-hydride shift. The 1-pro-S hydrogen of geranyl diphosphate is lost.
History
EC 4.2.3.115 created 2012
Reference
1  [PMID:736574]
  Authors
Poulose AJ, Croteau R
  Title
gamma-Terpinene synthetase: a key enzyme in the biosynthesis of aromatic monoterpenes.
  Journal
Arch Biochem Biophys 191:400-11 (1978)
DOI:10.1016/0003-9861(78)90104-2
Reference
2  [PMID:8460944]
  Authors
LaFever RE, Croteau R
  Title
Hydride shifts in the biosynthesis of the p-menthane monoterpenes alpha-terpinene, gamma-terpinene, and beta-phellandrene.
  Journal
Arch Biochem Biophys 301:361-6 (1993)
DOI:10.1006/abbi.1993.1156
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.115
IUBMB Enzyme Nomenclature: 4.2.3.115
ExPASy - ENZYME nomenclature database: 4.2.3.115
BRENDA, the Enzyme Database: 4.2.3.115

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (8)   
   UniProt (4)   
   SWISS-PROT (4)   
Protein domain (7)   
   InterPro (7)   
All databases (20)   

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