KEGG   ENZYME: 4.2.3.118
Entry
EC 4.2.3.118                Enzyme                                 
Name
2-methylisoborneol synthase;
sco7700;
2-MIB cyclase;
MIB synthase;
MIBS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming)
Reaction(IUBMB)
(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate [RN:R09973]
Reaction(KEGG)
R09973
Substrate
(E)-2-methylgeranyl diphosphate [CPD:C20235];
H2O [CPD:C00001]
Product
2-methylisoborneol [CPD:C20243];
diphosphate [CPD:C00013]
Comment
The product, 2-methylisoborneol, is a characteristc odiferous compound with a musty smell produced by soil microorganisms.
History
EC 4.2.3.118 created 2012
Orthology
K16218  2-methylisoborneol synthase
Genes
PFOPfl01_1841
PGYAWU82_02175
PATAJWU58_18120
PZEHU754_010805
PSAMHU731_003800
PASGKSS96_10535
PIEHU724_009960
PFITKJY40_10575
NANNO0S08_17685
NBRO3I_014430
NNONONO_c25610
NTPCRH09_13810
NOZDMB37_04600
NODFOH10_10105
NAHF5544_16850
NADNCTC11293_03086
NWLNWFMUON74_46170
NIEKV110_12995
NHUH0264_35815
NYALTV02_08300
NGPLTT66_01310
NSPUIFM12276_42340
NYUD7D52_22670
SCOSCO7700(SC1A4.08)
SGRSGR_1269
SANLKZO11_31020
SGRFSGFS_015730
SCBSCAB_5041 SCAB_82161
SVLStrvi_5648
SRCM271_41390
SMALSMALA_1169
SSOII1A49_09325
SFASfla_5667
SBHSBI_08957
SVESVEN_7111
SDVBN159_8264
STRPF750_0931
SCIB446_04425
SLVSLIV_00800
SVTSVTN_32730
STREGZL_00392 GZL_09219
SLDT261_0348 T261_0999
SLCSL103_24335
STRMM444_04660
STRCAA958_14455
SAMBSAM23877_0409
SPAVSpa2297_00460
STRTA8713_31595
SCLFBB341_02180
SGSAVL59_27410 AVL59_29235 AVL59_39200
STSIA4E84_39415
SALWCP975_03255
SGMGCM10017557_74180
SCADDN051_34585
SLSSLINC_0498
SNRSNOUR_01185 SNOUR_41450
SALUDC74_7952
SALLSAZ_41055
SNWBBN63_07290
SAUOBV401_09615
SPUNBFF78_28970 BFF78_39085
SGVB1H19_05230 B1H19_35415
SLAUSLA_6491
SALJSMD11_0058(mibs) SMD11_0841(mibs)
SLXSLAV_04745
STROSTRMOE7_31125
SFKKY5_0684
SGEDWG14_07887
SRJSRO_0472
SCYAEJ357_44455
SKACP970_39580
SGZC0216_28055
SVNCP980_02680
SHAWCEB94_39485
SRKFGW37_01930 FGW37_32355
SFICEIZ62_30005
SPADDVK44_33305
SAQUEJC51_43075
SGFHEP81_00455
SRIMCP984_02515
SSUBCP968_00375
SPHVF9278_00485 F9278_03905
SCINCP977_29565
SCHACP983_40850
SGXH4W23_02775
SBATG4Z16_17840
SNFJYK04_07625
SPLACP981_14275
SBROGQF42_05890
STUIGCM10017668_01900
SHUNDWB77_01162
SFEUIM697_25785
SMOBJ7W19_26425
SROIIAG44_02635
SXNIAG42_34310
SANUK7396_32465
SLFJEQ17_04895
SDECL3078_05395 L3078_40635(tcp)
SAOVG3H79_01805 G3H79_34955 G3H79_38800
SDURM4V62_02700
SYANNRK68_31495
SAKBK1J60_03050(tcp) K1J60_40655
STAALDH80_06875
SNIGHEK616_77090
SCAEIHE65_04050 IHE65_40850
STUBMMF93_30825
SSPNLXH13_02485
SCIRSTRCI_000420
SXTKPP03845_100514
SLONLGI35_41050
STUDSTRTU_004586
SGKPET44_03230
SANTQR300_37550
SYUNMOV08_01420 MOV08_42815
SOVQZH56_01770
SKGKJK29_37670
SCOAQU709_43165
SLAIP8A22_06355
SFPQUY26_00845
STTNBSL84_31405
SINNABB07_34905
KSKKSE_70210
KITCFP65_5033 CFP65_6965
KISHUT16_33510
YIALO772_33755
AGLAOIE69_40505
NDANdas_2620
NALB005_4057
NEXNE857_13500
NECKGD82_17075
NAKEKGD83_12565
NCGKGD84_21200
SNAHOUQ99_11115
ACTWF7P10_26540
AGRAAGRA3207_007829
AMAZLUW76_36550
ACIROG979_09485
ACTQOG417_08210
NOABKM31_10725
NOWGBF35_07420
NGNLCN96_30650
NFSOIE67_17575
SENSACE_3722
SACGFDZ84_36940
AMDAMED_3240
AMNRAM_16480
AMMAMES_3205
AMZB737_3205
AOIAORI_4062
AJAAJAP_18590
AMYCCU254_16060
AMYBBKN51_13190
AABA4R43_03950
AMYYYIM_16995
AORISD37_20725
APRTMUY14_19220
AROONQK81_00545
SESPBN6_59350
SSYIEKG83_30420
KALKALB_4605
KUTJJ691_11940
KPHYAOZ06_24430
LEDBBK82_32020
ALOCRK56091
CROSN8J89_36205
ASEACPL_2023
ACTSACWT_1901
AIHAiant_63900
ACTLL3i22_020270
ASICQ0Z83_001890
AOUACTOB_001988
ATLAthai_37800
CAICaci_4612 Caci_4614
SNASnas_1991
 » show all
Reference
1  [PMID:18563898]
  Authors
Wang CM, Cane DE
  Title
Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.
  Journal
J Am Chem Soc 130:8908-9 (2008)
DOI:10.1021/ja803639g
  Sequence
[sco:SCO7700]
Reference
2  [PMID:18492804]
  Authors
Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H
  Title
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.
  Journal
Proc Natl Acad Sci U S A 105:7422-7 (2008)
DOI:10.1073/pnas.0802312105
  Sequence
Reference
3  [PMID:21174459]
  Authors
Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT
  Title
Biosynthesis of 2-methylisoborneol in cyanobacteria.
  Journal
Environ Sci Technol 45:992-8 (2011)
DOI:10.1021/es102992p
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.118
IUBMB Enzyme Nomenclature: 4.2.3.118
ExPASy - ENZYME nomenclature database: 4.2.3.118
BRENDA, the Enzyme Database: 4.2.3.118

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