Entry
Name
alpha-muurolene synthase;
Cop3
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, alpha-muurolene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = alpha-muurolene + diphosphate [RN:
R10004 ]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:
C00448 ]
Product
Comment
The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and gamma-muurolene, see EC
4.2.3.23 , germacrene-A synthase and EC
4.2.3.126 , gamma-muurolene synthase.
History
EC 4.2.3.125 created 2012
Orthology
K21927 alpha-muurolene/germacrene-A/gamma-muurolene/(+)-delta-cadinol synthase
Genes
ABP : AGABI1DRAFT46681(AGABI1DRAFT_46681)
ABV : AGABI2DRAFT73543(AGABI2DRAFT_73543)
MRR : Moror_15644 Moror_7733
» show all
Taxonomy
Reference
Authors
Agger S, Lopez-Gallego F, Schmidt-Dannert C
Title
Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus.
Journal
Sequence
Reference
Authors
Lopez-Gallego F, Wawrzyn GT, Schmidt-Dannert C
Title
Selectivity of fungal sesquiterpene synthases: role of the active site's H-1 alpha loop in catalysis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.3.125