KEGG   ENZYME: 4.2.3.126
Entry
EC 4.2.3.126                Enzyme                                 
Name
gamma-muurolene synthase;
Cop3
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lase (cyclizing, gamma-muurolene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = gamma-muurolene + diphosphate [RN:R10005]
Reaction(KEGG)
R10005
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
gamma-muurolene [CPD:C20273];
diphosphate [CPD:C00013]
Comment
The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and alpha-muurolene, see EC 4.2.3.23, germacrene-A synthase and EC 4.2.3.125, alpha-muurolene synthase.
History
EC 4.2.3.126 created 2012
Orthology
K21927  alpha-muurolene/germacrene-A/gamma-muurolene/(+)-delta-cadinol synthase
Genes
DFR: 124500479
TVS: TRAVEDRAFT_75578
DSQ: DICSQDRAFT_124305
SHS: STEHIDRAFT_45387
HIR: HETIRDRAFT_167573
FME: FOMMEDRAFT_109318
GTR: GLOTRDRAFT_103889
CCI: CC1G_12294
ABP: AGABI1DRAFT46681(AGABI1DRAFT_46681)
ABV: AGABI2DRAFT73543(AGABI2DRAFT_73543)
PCUB: JR316_0003914
MPR: MPER_06109
MRR: Moror_15644 Moror_7733
MORE: E1B28_009287(COP3)
 » show all
Reference
1  [PMID:19400802]
  Authors
Agger S, Lopez-Gallego F, Schmidt-Dannert C
  Title
Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus.
  Journal
Mol Microbiol 72:1181-95 (2009)
DOI:10.1111/j.1365-2958.2009.06717.x
  Sequence
[cci:CC1G_12294]
Reference
2  [PMID:20889795]
  Authors
Lopez-Gallego F, Wawrzyn GT, Schmidt-Dannert C
  Title
Selectivity of fungal sesquiterpene synthases: role of the active site's H-1 alpha loop in catalysis.
  Journal
Appl Environ Microbiol 76:7723-33 (2010)
DOI:10.1128/AEM.01811-10
  Sequence
[cci:CC1G_12294]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.126
IUBMB Enzyme Nomenclature: 4.2.3.126
ExPASy - ENZYME nomenclature database: 4.2.3.126
BRENDA, the Enzyme Database: 4.2.3.126

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (16)   
Protein sequence (25)   
   UniProt (15)   
   SWISS-PROT (10)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (3)   
   InterPro (3)   
All databases (54)   

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