Entry
Name
beta-cubebene synthase;
cop4;
Mg25
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, beta-cubebene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = beta-cubebene + diphosphate [RN:
R10007 ]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:
C00448 ]
Product
Comment
Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-delta-cadinene, beta-copaene, (+)-sativene and traces of several other sequiterpenoids [2-4]. It is found in many higher plants such as Magnolia grandiflora (Southern Magnolia) together with germacrene A [1]. See EC
4.2.3.13 , (+)-delta-cadinene synthase, EC
4.2.3.127 , beta-copaene synthase, EC
4.2.3.129 , (+)-sativene synthase, and EC
4.2.3.23 , germacrene A synthase.
History
EC 4.2.3.128 created 2012
Orthology
K22058 cubebol/beta-copaene/beta-cubebene/(+)-sativene synthase
Genes
MSIN : 131221682 131221684 131221691
Taxonomy
Reference
Authors
Lee S, Chappell J
Title
Biochemical and genomic characterization of terpene synthases in Magnolia grandiflora.
Journal
Sequence
Reference
Authors
Agger S, Lopez-Gallego F, Schmidt-Dannert C
Title
Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus.
Journal
Sequence
Reference
Authors
Lopez-Gallego F, Agger SA, Abate-Pella D, Distefano MD, Schmidt-Dannert C
Title
Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers.
Journal
Sequence
Reference
Authors
Lopez-Gallego F, Wawrzyn GT, Schmidt-Dannert C
Title
Selectivity of fungal sesquiterpene synthases: role of the active site's H-1 alpha loop in catalysis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.3.128