Entry
Name
(+)-sativene synthase;
cop4
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-sativene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate [RN:
R10008 ]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:
C00448 ]
Product
Comment
Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-delta-cadinene, beta-copaene, beta-cubebene, and traces of several other sequiterpenoids. See EC
4.2.3.13 , (+)-delta-cadinene synthase, EC
4.2.3.127 , beta-copaene synthase, and EC
4.2.3.128 , beta-cubebene synthase.
History
EC 4.2.3.129 created 2012
Orthology
K22058 cubebol/beta-copaene/beta-cubebene/(+)-sativene synthase
Genes
Taxonomy
Reference
Authors
Agger S, Lopez-Gallego F, Schmidt-Dannert C
Title
Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus.
Journal
Sequence
Reference
Authors
Lopez-Gallego F, Agger SA, Abate-Pella D, Distefano MD, Schmidt-Dannert C
Title
Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers.
Journal
Sequence
Reference
Authors
Lopez-Gallego F, Wawrzyn GT, Schmidt-Dannert C
Title
Selectivity of fungal sesquiterpene synthases: role of the active site's H-1 alpha loop in catalysis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.3.129