KEGG   ENZYME: 4.2.3.133
Entry
EC 4.2.3.133                Enzyme                                 
Name
alpha-copaene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, alpha-copaene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (-)-alpha-copaene + diphosphate [RN:R10584]
Reaction(KEGG)
R10584
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(-)-alpha-copaene [CPD:C09639];
diphosphate [CPD:C00013]
Comment
Isolated from Helianthus annuus (sunflower). The enzyme also produces beta-caryophyllene, delta-cadinene and traces of other sesquiterpenoids. See EC 4.2.3.13 (+)-delta-cadinene synthase, EC 4.2.3.57 (-)-beta-caryophyllene synthase.
History
EC 4.2.3.133 created 2012
Orthology
K22065  alpha-copaene/(+)-delta-cadinene synthase
Genes
PVY: 116142924 116142925
HSYR: 120164486
QSA: O6P43_000875 O6P43_026144
RCU: 8280754
JCU: 105633238
MESC: 110610066
HAN: 110893972
ECAD: 122595886
Reference
1  [PMID:19580670]
  Authors
Gopfert JC, Macnevin G, Ro DK, Spring O
  Title
Identification, functional characterization and developmental regulation of sesquiterpene synthases from sunflower capitate glandular trichomes.
  Journal
BMC Plant Biol 9:86 (2009)
DOI:10.1186/1471-2229-9-86
  Sequence
[ag:AAY41422]
Reference
2  [PMID:22459969]
  Authors
Xie X, Kirby J, Keasling JD
  Title
Functional characterization of four sesquiterpene synthases from Ricinus communis (castor bean).
  Journal
Phytochemistry 78:20-8 (2012)
DOI:10.1016/j.phytochem.2012.02.022
  Sequence
[rcu:8280754]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.133
IUBMB Enzyme Nomenclature: 4.2.3.133
ExPASy - ENZYME nomenclature database: 4.2.3.133
BRENDA, the Enzyme Database: 4.2.3.133

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (11)   
Protein sequence (25)   
   UniProt (13)   
   SWISS-PROT (10)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (9)   
   InterPro (9)   
All databases (53)   

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