Entry
Name
Delta6-protoilludene synthase;
6-protoilludene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, Delta6-protoilludene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = Delta6-protoilludene + diphosphate [RN:
R10271 ]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:
C00448 ]
Product
Comment
Isolated from the fungus Armillaria gallica. Delta6-Protoilludene is the first step in the biosynthesis of the melleolides.
History
EC 4.2.3.135 created 2012
Orthology
K22062 Delta6-protoilludene synthase
Genes
DSQ : DICSQDRAFT_57723 DICSQDRAFT_58025
HIR : HETIRDRAFT_148791(tcc1) HETIRDRAFT_446121
PSQ : PUNSTDRAFT_108886 PUNSTDRAFT_62271
FME : FOMMEDRAFT_112446 FOMMEDRAFT_170128
SLA : SERLADRAFT_441878(cyc6)
» show all
Taxonomy
Reference
Authors
Engels B, Heinig U, Grothe T, Stadler M, Jennewein S
Title
Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.3.135