Entry Name cyclooctat-9-en-7-ol synthase;
Class Lyases;BRITE hierarchy
Sysname geranylgeranyl-diphosphate diphosphate-lyase (cyclooctat-9-en-7-ol-forming)
Reaction(IUBMB) geranylgeranyl diphosphate + H2O = cyclooctat-9-en-7-ol + diphosphate [RN:
R10763 ]
Reaction(KEGG) Substrate Product Comment Requires Mg2+. Isolated from the bacterium Streptomyces melanosporofaciens, where it is part of the biosynthesis of cyclooctatin, a potent inhibitor of lysophospholipase.
History EC 4.2.3.146 created 2014
Pathway ec00997 Biosynthesis of various other secondary metabolites
ec01110 Biosynthesis of secondary metabolites
Orthology K18686 cyclooctat-9-en-7-ol synthase
Genes Taxonomy Reference Authors Kim SY, Zhao P, Igarashi M, Sawa R, Tomita T, Nishiyama M, Kuzuyama T
Title Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
Journal Sequence Reference Authors Zhang X, Shang G, Gu L, Shen Y
Title Crystallization and preliminary X-ray diffraction analysis of the diterpene cyclooctatin synthase (CYC) from Streptomyces sp. LZ35.
Journal Reference Authors Janke R, Gorner C, Hirte M, Bruck T, Loll B
Title The first structure of a bacterial diterpene cyclase: CotB2.
Journal Reference Authors Meguro A, Motoyoshi Y, Teramoto K, Ueda S, Totsuka Y, Ando Y, Tomita T, Kim SY, Kimura T, Igarashi M, Sawa R, Shinada T, Nishiyama M, Kuzuyama T
Title An unusual terpene cyclization mechanism involving a carbon-carbon bond rearrangement.
Journal Reference Authors Tomita T, Kim SY, Teramoto K, Meguro A, Ozaki T, Yoshida A, Motoyoshi Y, Mori N, Ishigami K, Watanabe H, Nishiyama M, Kuzuyama T
Title Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol.
Journal Other DBs ExPASy - ENZYME nomenclature database: 4.2.3.146
