KEGG   ENZYME: 4.2.3.15
Entry
EC 4.2.3.15                 Enzyme                                 
Name
myrcene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranyl-diphosphate diphosphate-lyase (myrcene-forming)
Reaction(IUBMB)
geranyl diphosphate = myrcene + diphosphate [RN:R02009]
Reaction(KEGG)
R02009
Substrate
geranyl diphosphate [CPD:C00341]
Product
myrcene [CPD:C06074];
diphosphate [CPD:C00013]
Comment
A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor.
History
EC 4.2.3.15 created 2000 as EC 4.1.99.9, transferred 2000 to EC 4.2.3.15
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K12467  myrcene/ocimene synthase
K21925  (-)-camphene/tricyclene/(4S)-limonene/myrcene synthase
Genes
ATHAT2G24210(TPS10) AT3G25810
CRB17889158 17889311
CSAT104702938
BRP103858386 103858582
BNA106385578 106402047 106443840
BOE106328108 106334082
RSZ108837661 108846403 108846672
TWL119980547
SLY101245212(TPS3) 101249864
SPEN107012939 107012948
SOT102591915 102602070
SSTN125861389 125861571
CANN107840093
LBB132598839
NTA107785945 107787835
NSY104238653
NTO104090536
NAU109214608
SSPL121755010
SMIL131005775 131026618 131026619
MSIN131221635
 » show all
Reference
1  [PMID:9268308]
  Authors
Bohlmann J, Steele CL, Croteau R
  Title
Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase.
  Journal
J Biol Chem 272:21784-92 (1997)
DOI:10.1074/jbc.272.35.21784
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.15
IUBMB Enzyme Nomenclature: 4.2.3.15
ExPASy - ENZYME nomenclature database: 4.2.3.15
BRENDA, the Enzyme Database: 4.2.3.15
CAS: 197462-59-2

DBGET integrated database retrieval system