KEGG   ENZYME: 4.2.3.151
Entry
EC 4.2.3.151                Enzyme                                 
Name
pentamethylcyclopentadecatrienol synthase;
DtcycB (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase [(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol-forming]
Reaction(IUBMB)
geranylgeranyl diphosphate + H2O = (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate [RN:R10899]
Reaction(KEGG)
R10899
Substrate
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Product
(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol [CPD:C20924];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This trifunctional enzyme, which contains a [4Fe-4S] cluster, also produces (R)-nephthenol and (R)-cembrene A. See EC 4.2.3.150, cembrene A synthase and EC 4.2.3.149, nephthenol synthase.
History
EC 4.2.3.151 created 2014
Orthology
K20505  nephthenol/cembrene A/pentamethylcyclopentadecatrienol synthase
Reference
1  [PMID:23386483]
  Authors
Meguro A, Tomita T, Nishiyama M, Kuzuyama T
  Title
Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton.
  Journal
Chembiochem 14:316-21 (2013)
DOI:10.1002/cbic.201200651
  Sequence
[ag:BAM78698]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.151
IUBMB Enzyme Nomenclature: 4.2.3.151
ExPASy - ENZYME nomenclature database: 4.2.3.151
BRENDA, the Enzyme Database: 4.2.3.151

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (1)   
   InterPro (1)   
All databases (11)   

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