KEGG   ENZYME: 4.2.3.156
Entry
EC 4.2.3.156                Enzyme                                 
Name
hydroxysqualene synthase;
hpnC (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
presqualene diphosphate diphosphate-lyase (adding water; hydroxyasqualene-forming)
Reaction(IUBMB)
presqualene diphosphate + H2O = hydroxysqualene + diphosphate [RN:R11410]
Reaction(KEGG)
R11410
Substrate
presqualene diphosphate [CPD:C03428];
H2O [CPD:C00001]
Product
hydroxysqualene [CPD:C21116];
diphosphate [CPD:C00013]
Comment
This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 1.17.8.1, hydroxysqualene dehydroxylase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase.
History
EC 4.2.3.156 created 2016
Orthology
K21679  hydroxysqualene synthase
Genes
MEJ: Q7A_951(hpnC)
MEC: Q7C_988
HHC: M911_10410
EBS: ECTOBSL9_3058
TGR: Tgr7_1525
TKM: TK90_1510
TNI: TVNIR_1520
APRS: BI364_06325
TTC: FOKN1_2196
REV: HUE57_10345(hpnC)
RAC: RA876_07090
RHY: RD110_09935
RHG: EXZ61_07460(hpnC)
POS: DT070_19910(hpnC)
POO: F7R28_10650(hpnC)
AJS: Ajs_1205
ACRA: BSY15_67(hpnC)
ACID: CBP33_06850
ACIP: CBP36_07420
ACIN: CBP34_06750
ACIS: CBP35_11510
ACIO: EAG14_07725(hpnC)
AMON: H9L24_00435(hpnC)
DAC: Daci_2573
DEL: DelCs14_4080
DTS: BI380_11400
DHK: BO996_12125
DLA: I6G47_11335(hpnC)
VPE: Varpa_3427
VAA: AX767_18370
VBO: CKY39_15560(hpnC)
VAM: C4F17_07375(hpnC)
CTT: CtCNB1_1247
CTES: O987_06870
COF: FOZ74_15310(hpnC)
AANT: HUK68_06680(hpnC)
OTO: ADJ79_01055
LIM: L103DPR2_02181(crtB_2)
HYR: BSY239_1397(hpnC)
HYB: Q5W_23335
HYL: LPB072_13490
HPSE: HPF_15100(crtB1)
HYN: F9K07_17405(hpnC)
DIH: G7047_03060(hpnC)
DAER: H9K75_19365(hpnC)
DRG: H9K76_16410(hpnC)
DIA: Dtpsy_1124
CBAA: SRAA_0599
CBAB: SMCB_1449
STHM: IS481_11010
PBH: AAW51_1823
RGE: RGE_27980
RBN: RBXJA2T_19156
PKT: AT984_04180
MIU: ABE85_14150
LCH: Lcho_2548
RGU: A4W93_10810
ABRE: pbN1_35070(hpnC)
APET: ToN1_08500(hpnC)
PMOB: HG718_04890
KMN: HW532_17980(hpnC)
PECT: BN1012_Phect104
RHI: NGR_a00430
SINO: SS05631_a45160
ESJ: SJ05684_a40260
BJA: blr3001(blr3001)
BJU: BJ6T_67660
BJP: RN69_32815
BRA: BRADO2627
BBT: BBta_2966
BRS: S23_49960(sqs)
AOL: S58_49920
BRC: BCCGELA001_13460
BRAD: BF49_1691
BIC: LMTR13_28345
BRO: BRAD285_4714
BRK: CWS35_18210(hpnC)
BOT: CIT37_38590(hpnC)
BRQ: CIT40_09505(hpnC)
BGQ: X265_25995(hpnC)
BGZ: XH91_24135(hpnC)
BSYM: CIT39_08625(hpnC)
BBET: F8237_05040(hpnC)
BARH: WN72_16435(hpnC)
BVZ: BRAD3257_5709
BEL: BE61_70470
BDG: LPJ38_18005(hpnC)
BSEP: HAP48_0030885(hpnC)
BQB: J4P68_0032145(hpnC)
BSEI: KMZ68_09705(hpnC)
BBAN: J4G43_017120(hpnC)
BCAN: BcanWSM471_14280(hpnC)
BAUT: QA635_28535(hpnC)
BBRA: QA636_30425(hpnC)
BGK: IC762_11715(hpnC)
BCOU: IC761_24430(hpnC)
BPAH: QA639_15455(hpnC)
BXN: I3J27_11360(hpnC)
BROS: QUH67_11915(hpnC)
BRAZ: LRP30_12825(hpnC)
RPA: TX73_019385(hpnC)
RPB: RPB_1723
RPC: RPC_1717
RPD: RPD_3576
RPE: RPE_1811
RPT: Rpal_4264
RPX: Rpdx1_1602
RBK: E0H22_09825(hpnC)
NWI: Nwi_2272
NHA: Nham_2685
OCA: OCAR_6674(hpnC)
OCG: OCA5_c13940
OCO: OCA4_c13940
PCAX: AFIC_002156(hpnC)
VGO: GJW-30_1_02139(crtB_1)
TRB: HB776_13770(hpnC)
TALZ: RPMA_20065(hpnC)
STAR: G3545_15495(hpnC)
MEA: Mex_1p1815
MDI: METDI2702
MEX: Mext_1941
MCH: Mchl_2217
MPO: Mpop_1832
MZA: B2G69_17165
MRD: Mrad2831_5423
MET: M446_6350
MNO: Mnod_7143
MOR: MOC_5998(hpnC)
META: Y590_09025
MAQU: Maq22A_c25240(erg9)
MPHY: MCBMB27_04724
MEE: DA075_06160(hpnC)
METD: C0214_10780(hpnC)
METX: A3862_03560
METS: DK389_19270(hpnC)
METI: DK427_24620(hpnC)
MMES: MMSR116_24440(hpnC)
MTEA: DK419_24995(hpnC)
MIND: mvi_55640
MOG: MMB17_13735(hpnC)
MTAD: M6G65_20540(hpnC)
MOC: BB934_38310
MTEZ: HPT29_002665
MLD: U0023_10040
BID: Bind_3153
MSL: Msil_3240
MTUN: MTUNDRAET4_2108
MLG: CWB41_01830(hpnC)
MEDK: QEV83_07980(hpnC)
BBAR: RHAL1_00131(hpnC)
HDN: Hden_0474
HDT: HYPDE_24873
HMC: HYPMC_3774
RVA: Rvan_3020
RLAC: QMO75_10880(hpnC)
RHZ: RHPLAN_23280
MSC: BN69_1681
MBRY: B1812_03905
MROS: EHO51_00865(hpnC)
MHEY: H2LOC_015890(hpnC)
MPAR: F7D14_11080(hpnC)
MIWA: SS37A_09930
MTW: CQW49_11740(hpnC)
MECQ: MSC49_02500
PSIN: CAK95_04470
TSO: IZ6_27220
RBM: TEF_04825
LIZ: LGH83_10460(hpnC)
CAUL: KCG34_23160(hpnC)
PLCG: RVY76_15985
PALW: PSAL_001920(hpnC)
LVR: T8T21_16655
ZMO: ZMO0869
ZMN: Za10_0423
ZMM: Zmob_0428
ZMB: ZZ6_0426
ZMI: ZCP4_0442
ZMC: A265_00437
ZMR: A254_00437
ZMP: Zymop_0396
NOR: FA702_05050(hpnC)
NHUM: PQ457_14485(hpnC)
SPHM: G432_09195
SPAN: AWL63_21305
SPHA: D3Y57_13880(hpnC)
SARI: H5J25_10655(hpnC)
SMOR: LHA26_10005(hpnC)
SNOS: K8P63_14025(hpnC)
SABI: PBT88_02330(hpnC)
POQ: KZX46_17590(hpnC)
PMEA: KTC28_15780(hpnC)
GOX: GOX2255
GOH: B932_2747
GOY: GLS_c23980(hpnC)
GAL: A0U94_06145
GTI: FXF46_13800(hpnC)
GSP: IGS75_12740(hpnC)
GFA: MKW11_14230(hpnC)
GBE: GbCGDNIH1_1980
GBH: GbCGDNIH2_1980
GBC: GbCGDNIH3_1980
GBS: GbCGDNIH4_1980
ACR: Acry_0119
AMV: ACMV_01440
GDI: GDI1623
GDJ: Gdia_1828
GXY: GLX_17360
GXL: H845_3226
KNA: B0W47_08885
KEU: S101446_02252
KSC: CD178_01162(crtB_2)
KRE: GWK63_14330(hpnC)
KOI: LV478_05320(hpnC)
APT: APA01_01980
APW: APA42C_01980
APF: APA03_01980
APU: APA07_01980
APG: APA12_01980
APQ: APA22_01980
APX: APA26_01980
APZ: APA32_01980
APK: APA386B_1686
ASZ: ASN_2211
ASV: WG31_01030
AACE: A0U92_11685
APER: A0U91_06960
APOM: CPF11_06310(hpnC)
ATO: CIW82_01575(hpnC)
AASC: A4S02_11550
ACET: DS739_01130(hpnC)
AOT: AcetOri_orf02398
AOY: EOV40_001055(hpnC)
ACEK: FLP30_07015(hpnC)
ABG: Asbog_02599(hpnC)
KBA: A0U89_01800
RGI: RGI145_09715
ROS: CTJ15_07705(hpnC)
RMUC: FOB66_09730(hpnC)
RMT: IAI58_18580(hpnC)
NCH: A0U93_07560
COQ: D9V35_08235
COMM: GN303_08035
NTN: D5366_10580
NEH: E3E11_07650(hpnC)
SSAM: E3D00_09650(hpnC)
SWF: E3E12_06915(hpnC)
BOB: GN304_03805(hpnC)
BOMB: GT348_03330(hpnC)
EBLA: JGUZn3_04120(hpnC)
LCK: HN018_00155(hpnC)
KHA: IFJ82_01370(hpnC)
PARZ: DTQ13_08060(hpnC)
SRF: LHU95_04740
RAP: RHOA_2342(hpnC)
ACIM: GT370_09620(hpnC)
KDP: N5W20_09455(hpnC)
NGU: QN315_11450(hpnC)
SHUM: STHU_32410
SVC: STVA_19130
STEL: STAQ_29110
AZL: AZL_014590
ALI: AZOLI_1387
ABS: AZOBR_p120090
ABQ: ABAZ39_16795
ABF: AMK58_16910
ATI: AL072_11965
AHU: A6A40_05005
AZT: TSH58p_22390
AZM: DM194_04400
AOZ: HUE56_17240
AARE: D3093_17175
AZS: E6C72_10490
NAO: Y958_17505 Y958_22685(hpnC)
NCB: C0V82_03560
SKT: IGS68_10430(hpnC)
SMUC: JL100_016805
SROE: JL101_015655(hpnC)
RRU: Rru_A0065
RRF: F11_00330
RCE: RC1_1044
RPM: RSPPHO_00434
MGY: MGMSRv2__1218
MGRY: MSR1_10410(crtB_2)
MAGX: XM1_3269
MAGN: WV31_06945
DEX: HWD60_06300 HWD60_12250(hpnC)
DVN: HQ394_07745(hpnC)
MAG: amb2509
HJO: AY555_08490
HTQ: FRZ44_04120
HADH: FRZ61_04380
MAGQ: MGMAQ_1490
VSU: P3M64_01205
THAR: T8K17_14480
HFL: PUV54_13170(hpnC)
MAES: Ga0123461_1321
MFN: Ga0123462_1081
RIA: C7V51_14810
LFC: LFE_1960
LFI: LFML04_2158
LFP: Y981_11065
LEG: ABH19_11635
 » show all
Reference
1  [PMID:26258173]
  Authors
Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD
  Title
Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes.
  Journal
ACS Cent Sci 1:77-82 (2015)
DOI:10.1021/acscentsci.5b00115
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.156
IUBMB Enzyme Nomenclature: 4.2.3.156
ExPASy - ENZYME nomenclature database: 4.2.3.156
BRENDA, the Enzyme Database: 4.2.3.156

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (1420)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (304)   
   KEGG MGENES (814)   
   RefGene (301)   
Protein sequence (32)   
   UniProt (29)   
   SWISS-PROT (3)   
DNA sequence (139)   
   GenBank (70)   
   EMBL (69)   
Protein domain (5)   
   InterPro (5)   
All databases (1602)   

Download RDF
DBGET integrated database retrieval system