KEGG   ENZYME: 4.2.3.157
Entry
EC 4.2.3.157                Enzyme                                 
Name
(+)-isoafricanol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-isoafricanol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate [RN:R11822]
Reaction(KEGG)
R11822
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(+)-isoafricanol [CPD:C21660];
diphosphate [CPD:C00013]
Comment
(+)-Isoafricanol is a sesquiterpene alcohol. Its synthesis has been shown to occur in the bacteria Streptomyces violaceusniger and Streptomyces malaysiensis.
History
EC 4.2.3.157 created 2017
Orthology
K23043  (+)-isoafricanol synthase
Genes
SVL: Strvi_5748
SRC: M271_43390
SMAL: SMALA_0716
SSOI: I1A49_07175
SBH: SBI_01080
SAUO: BV401_07430
SANT: QR300_37035
Reference
1  [PMID:24626486]
  Authors
Riclea R, Citron CA, Rinkel J, Dickschat JS
  Title
Identification of isoafricanol and its terpene cyclase in Streptomyces violaceusniger using CLSA-NMR.
  Journal
Chem Commun (Camb) 50:4228-30 (2014)
DOI:10.1039/c4cc00177j
  Sequence
[svl:Strvi_5748]
Reference
2  [PMID:28247907]
  Authors
Rabe P, Samborskyy M, Leadlay PF, Dickschat JS
  Title
Isoafricanol synthase from Streptomyces malaysiensis.
  Journal
Org Biomol Chem 15:2353-2358 (2017)
DOI:10.1039/c7ob00234c
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.157
IUBMB Enzyme Nomenclature: 4.2.3.157
ExPASy - ENZYME nomenclature database: 4.2.3.157
BRENDA, the Enzyme Database: 4.2.3.157

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (7)   
Protein sequence (146)   
   UniProt (3)   
   SWISS-PROT (3)   
   RefSeq(pep) (140)   
DNA sequence (188)   
   RefSeq(nuc) (173)   
   GenBank (9)   
   EMBL (6)   
Protein domain (4)   
   InterPro (4)   
All databases (351)   

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