Entry |
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Name |
|
Class |
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
|
Sysname |
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, tsukubadiene-forming)
|
Reaction(IUBMB) |
geranylgeranyl diphosphate = tsukubadiene + diphosphate [RN: R11824]
|
Reaction(KEGG) |
|
Substrate |
geranylgeranyl diphosphate [CPD: C00353]
|
Product |
|
Comment |
The synthesis of the diterpene tsukubadiene has been shown to occur in the Actinobacterium Streptomyces tsukubaensis.
|
History |
EC 4.2.3.159 created 2017
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Orthology |
|
Genes |
|
Reference |
|
Authors |
Yamada Y, Arima S, Nagamitsu T, Johmoto K, Uekusa H, Eguchi T, Shin-ya K, Cane DE, Ikeda H |
Title |
Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host. |
Journal |
|
Reference |
|
Authors |
Rabe P, Rinkel J, Dolja E, Schmitz T, Nubbemeyer B, Luu TH, Dickschat JS |
Title |
Mechanistic Investigations of Two Bacterial Diterpene Cyclases: Spiroviolene Synthase and Tsukubadiene Synthase. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 4.2.3.159 |
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