KEGG   ENZYME: 4.2.3.166
Entry
EC 4.2.3.166                Enzyme                                 
Name
(+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol + diphosphate [RN:R11831]
Reaction(KEGG)
R11831
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol [CPD:C21686];
diphosphate [CPD:C00013]
Comment
The enzyme has been identified in the bacterium Streptomyces pratensis. It is specific for (2E,6E)-farnesyl diphosphate.
History
EC 4.2.3.166 created 2017
Orthology
K23024  (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol synthase
Genes
SFA: Sfla_1617
STRP: F750_5240
Reference
1  [PMID:26361082]
  Authors
Rabe P, Barra L, Rinkel J, Riclea R, Citron CA, Klapschinski TA, Janusko A, Dickschat JS
  Title
Conformational Analysis, Thermal Rearrangement, and EI-MS Fragmentation Mechanism of (1(10)E,4E,6S,7R)-Germacradien-6-ol by (13)C-Labeling Experiments.
  Journal
Angew Chem Int Ed Engl 54:13448-51 (2015)
DOI:10.1002/anie.201507615
  Sequence
[sfa:Sfla_1617]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.166
IUBMB Enzyme Nomenclature: 4.2.3.166
ExPASy - ENZYME nomenclature database: 4.2.3.166
BRENDA, the Enzyme Database: 4.2.3.166

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (34)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (31)   
DNA sequence (67)   
   RefSeq(nuc) (60)   
   GenBank (4)   
   EMBL (3)   
Protein domain (3)   
   InterPro (3)   
All databases (112)   

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