KEGG   ENZYME: 4.2.3.173
Entry
EC 4.2.3.173                Enzyme                                 
Name
tau-cadinol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, tau-cadinol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = tau-cadinol + diphosphate [RN:R11838]
Reaction(KEGG)
R11838
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
tau-cadinol [CPD:C21695];
diphosphate [CPD:C00013]
Comment
Isolated from the plant Inula hupehensis. The enzyme also gives 10-epi-juneol and traces of other terpenoids, see EC 4.2.3.172, 10-epi-juneol synthase. It has also been isolated from the plants maize (Zea mays) and lavender (Lavandula angustifolia).
History
EC 4.2.3.173 created 2017
Reference
1  [PMID:27231873]
  Authors
Gou JB, Li ZQ, Li CF, Chen FF, Lv SY, Zhang YS
  Title
Molecular cloning and functional analysis of a 10-epi-junenol synthase from Inula hupehensis.
  Journal
Plant Physiol Biochem 106:288-94 (2016)
DOI:10.1016/j.plaphy.2016.05.023
  Sequence
[ag:AMQ26035]
Reference
2  [PMID:24078339]
  Authors
Jullien F, Moja S, Bony A, Legrand S, Petit C, Benabdelkader T, Poirot K, Fiorucci S, Guitton Y, Nicole F, Baudino S, Magnard JL
  Title
Isolation and functional characterization of a tau-cadinol synthase, a new sesquiterpene synthase from Lavandula angustifolia.
  Journal
Plant Mol Biol 84:227-41 (2014)
DOI:10.1007/s11103-013-0131-3
  Sequence
[ag:AGL98418]
Reference
3  [PMID:27421723]
  Authors
Ren F, Mao H, Liang J, Liu J, Shu K, Wang Q
  Title
Functional characterization of ZmTPS7 reveals a maize tau-cadinol synthase involved in stress response.
  Journal
Planta 244:1065-1074 (2016)
DOI:10.1007/s00425-016-2570-y
  Sequence
[zma:542156]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.173
IUBMB Enzyme Nomenclature: 4.2.3.173
ExPASy - ENZYME nomenclature database: 4.2.3.173
BRENDA, the Enzyme Database: 4.2.3.173

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Protein sequence (8)   
   UniProt (5)   
   SWISS-PROT (3)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (7)   
   InterPro (7)   
All databases (24)   

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