KEGG   ENZYME: 4.2.3.175
Entry
EC 4.2.3.175                Enzyme                                 
Name
10-epi-cubebol synthase;
sce6369
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, 10-epi-cubebol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = 10-epi-cubebol + diphosphate [RN:R11840]
Reaction(KEGG)
R11840
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
10-epi-cubebol [CPD:C21700];
diphosphate [CPD:C00013]
Comment
Isolated from the bacterium Sorangium cellulosum So ce56. The enzyme is also responsible for the formation of trace amounts of many other sesquiterpenes, mainly cadinanes and cubebanes.
History
EC 4.2.3.175 created 2017
Orthology
K23031  10-epi-cubebol synthase
Genes
SCL: sce6369
Reference
1  [PMID:26947062]
  Authors
Schifrin A, Khatri Y, Kirsch P, Thiel V, Schulz S, Bernhardt R
  Title
A single terpene synthase is responsible for a wide variety of sesquiterpenes in Sorangium cellulosum Soce56.
  Journal
Org Biomol Chem 14:3385-93 (2016)
DOI:10.1039/c6ob00130k
  Sequence
[scl:sce6369]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.175
IUBMB Enzyme Nomenclature: 4.2.3.175
ExPASy - ENZYME nomenclature database: 4.2.3.175
BRENDA, the Enzyme Database: 4.2.3.175

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   PDBSTR (2)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   InterPro (3)   
All databases (15)   

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