KEGG   ENZYME: 4.2.3.176
Entry
EC 4.2.3.176                Enzyme                                 
Name
sesterfisherol synthase;
NfSS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E,10E,14E)-geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, sesterfisherol-forming)
Reaction(IUBMB)
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = sesterfisherol + diphosphate [RN:R11841]
Reaction(KEGG)
R11841
Substrate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate [CPD:C04217];
H2O [CPD:C00001]
Product
sesterfisherol [CPD:C21701];
diphosphate [CPD:C00013]
Comment
Isolated from the fungus Neosartorya fischeri.
History
EC 4.2.3.176 created 2017
Orthology
K23032  sesterfisherol synthase
Genes
AFM: AFUA_6G09830
NFI: NFIA_055550
ALUC: AKAW2_80669S
Reference
1  [PMID:26332841]
  Authors
Ye Y, Minami A, Mandi A, Liu C, Taniguchi T, Kuzuyama T, Monde K, Gomi K, Oikawa H
  Title
Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes.
  Journal
J Am Chem Soc 137:11846-53 (2015)
DOI:10.1021/jacs.5b08319
  Sequence
[nfi:NFIA_055550]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.176
IUBMB Enzyme Nomenclature: 4.2.3.176
ExPASy - ENZYME nomenclature database: 4.2.3.176
BRENDA, the Enzyme Database: 4.2.3.176

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (3)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (14)   

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