KEGG   ENZYME: 4.2.3.180
Entry
EC 4.2.3.180                Enzyme                                 
Name
pseudolaratriene synthase;
PxaTPS8
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, pseudolaradiene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = pseudolaratriene + diphosphate [RN:R11845]
Reaction(KEGG)
R11845
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
pseudolaratriene [CPD:C21706];
diphosphate [CPD:C00013]
Comment
Isolated from the plant Pseudolarix amabilis (golden larch). The product is oxidized to pseudolaric acid B, a microtubule-destabilizing agent.
History
EC 4.2.3.180 created 2017
Reference
1  [PMID:28096378]
  Authors
Mafu S, Karunanithi PS, Palazzo TA, Harrod BL, Rodriguez SM, Mollhoff IN, O'Brien TE, Tong S, Fiehn O, Tantillo DJ, Bohlmann J, Zerbe P
  Title
Biosynthesis of the microtubule-destabilizing diterpene pseudolaric acid B from golden larch involves an unusual diterpene synthase.
  Journal
Proc Natl Acad Sci U S A 114:974-979 (2017)
DOI:10.1073/pnas.1612901114
  Sequence
[ag:APT40486]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.180
IUBMB Enzyme Nomenclature: 4.2.3.180
ExPASy - ENZYME nomenclature database: 4.2.3.180
BRENDA, the Enzyme Database: 4.2.3.180

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (8)   
   InterPro (8)   
All databases (14)   

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