KEGG   ENZYME: 4.2.3.182
Entry
EC 4.2.3.182                Enzyme                                 
Name
pristinol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-(2S,3R,9R)-pristinol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate [RN:R11847]
Reaction(KEGG)
R11847
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(+)-(2S,3R,9R)-pristinol [CPD:C21708];
diphosphate [CPD:C00013]
Comment
Isolated from the bacterium Streptomyces pristinaespiralis.
History
EC 4.2.3.182 created 2017
Orthology
K23045  pristinol synthase
Genes
SPRISPRI_6538
Reference
1  [PMID:27403888]
  Authors
Klapschinski TA, Rabe P, Dickschat JS
  Title
Pristinol, a Sesquiterpene Alcohol with an Unusual Skeleton from Streptomyces pristinaespiralis.
  Journal
Angew Chem Int Ed Engl 55:10141-4 (2016)
DOI:10.1002/anie.201605425
  Sequence
[spri:SPRI_6538]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.182
IUBMB Enzyme Nomenclature: 4.2.3.182
ExPASy - ENZYME nomenclature database: 4.2.3.182
BRENDA, the Enzyme Database: 4.2.3.182

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