KEGG   ENZYME: 4.2.3.183
Entry
EC 4.2.3.183                Enzyme                                 
Name
nezukol synthase;
TPS2
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, nezukol-forming)
Reaction(IUBMB)
(+)-copalyl diphosphate + H2O = nezukol + diphosphate [RN:R11848]
Reaction(KEGG)
R11848
Substrate
(+)-copalyl diphosphate [CPD:C11901];
H2O [CPD:C00001]
Product
nezukol [CPD:C21709];
diphosphate [CPD:C00013]
Comment
Isolated from the plant Isodon rubescens.
History
EC 4.2.3.183 created 2017
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22945  nezukol synthase
Reference
1  [PMID:28445526]
  Authors
Pelot KA, Hagelthorn DM, Addison JB, Zerbe P
  Title
Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases.
  Journal
PLoS One 12:e0176507 (2017)
DOI:10.1371/journal.pone.0176507
  Sequence
[ag:ARO38140]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.183
IUBMB Enzyme Nomenclature: 4.2.3.183
ExPASy - ENZYME nomenclature database: 4.2.3.183
BRENDA, the Enzyme Database: 4.2.3.183

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (3)   
   UniProt (2)   
   SWISS-PROT (1)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (6)   
   InterPro (6)   
All databases (22)   

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