KEGG ENZYME: 4.2.3.188

ENZYME: 4.2.3.188

Entry

EC 4.2.3.188                Enzyme

Name

beta-geranylfarnesene synthase;
Bcl-TS

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

all-trans-geranylfarnesyl-diphosphate diphosphate-lyase (beta-geranylfarnesene-forming)

Reaction(IUBMB)

(1) all-trans-geranylfarnesyl diphosphate = beta-geranylfarnesene + diphosphate [RN:R11853];
(2) all-trans-hexaprenyl diphosphate = beta-hexaprene + diphosphate [RN:R11854];
(3) all-trans-heptaprenyl diphosphate = beta-heptaprene + diphosphate [RN:R11855]

Reaction(KEGG)

R11853 R11854 R11855

Substrate

all-trans-geranylfarnesyl diphosphate [CPD:C04217];
all-trans-hexaprenyl diphosphate [CPD:C01230];
all-trans-heptaprenyl diphosphate [CPD:C04216]

Product

beta-geranylfarnesene [CPD:C21716];
diphosphate [CPD:C00013];
beta-hexaprene [CPD:C21717];
beta-heptaprene [CPD:C21718]

Comment

Isolated from the bacterium Bacillus clausii. The enzyme acts on a range of polyprenyl diphosphates.

History

EC 4.2.3.188 created 2017

Reference

1 [PMID:23554321]

Authors

Sato T, Yamaga H, Kashima S, Murata Y, Shinada T, Nakano C, Hoshino T

Title

Identification of novel sesterterpene/triterpene synthase from Bacillus clausii.

Journal

Chembiochem 14:822-5 (2013)
DOI:10.1002/cbic.201300035

Sequence

[bcl:ABC1218]

Reference

2 [PMID:25882275]

Authors

Ueda D, Yamaga H, Murakami M, Totsuka Y, Shinada T, Sato T

Title

Biosynthesis of Sesterterpenes, Head-to-Tail Triterpenes, and Sesquarterpenes in Bacillus clausii: Identification of Multifunctional Enzymes and Analysis of Isoprenoid Metabolites.

Journal

Chembiochem 16:1371-7 (2015)
DOI:10.1002/cbic.201500138

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.188

IUBMB Enzyme Nomenclature:

4.2.3.188

ExPASy - ENZYME nomenclature database:

4.2.3.188

BRENDA, the Enzyme Database:

4.2.3.188

All links

Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG REACTION (3)   
   KEGG RCLASS (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (1)   
   InterPro (1)   
All databases (14)   

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