| Entry |
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| Name |
9,13-epoxylabd-14-ene synthase;
ELS (gene name);
TPS2 (gene name) (ambiguous);
peregrinol-diphosphate diphosphate-lyase (9,13-epoxylabd-14-ene-forming)
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| Class |
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
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| Sysname |
peregrinol-diphosphate diphosphate-lyase [(13R)-9,13-epoxylabd-14-ene-forming]
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| Reaction(IUBMB) |
peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate [RN: R11856]
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| Reaction(KEGG) |
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| Substrate |
peregrinol diphosphate [CPD: C21658]
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| Product |
(13R)-9,13-epoxylabd-14-ene [CPD: C21720];
diphosphate [CPD: C00013]
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| Comment |
Isolated from the plants Marrubium vulgare (white horehound) and Vitex agnus-castus (chaste tree). Involved in marrubiin biosynthesis.
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| History |
EC 4.2.3.189 created 2017
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| Reference |
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| Authors |
Zerbe P, Chiang A, Dullat H, O'Neil-Johnson M, Starks C, Hamberger B, Bohlmann J |
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| Title |
Diterpene synthases of the biosynthetic system of medicinally active diterpenoids in Marrubium vulgare. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Heskes AM, Sundram TCM, Boughton BA, Jensen NB, Hansen NL, Crocoll C, Cozzi F, Rasmussen S, Hamberger B, Hamberger B, Staerk D, Moller BL, Pateraki I |
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| Title |
Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 4.2.3.189 |
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